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   Articles with "pas domain" as a keyword



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Structure-Based Design of Versatile Biosensors for Small Molecules Based on the PAS Domain of a Thermophilic Histidine Kinase.

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recommendations! Published in 2018 at "ACS synthetic biology"

DOI: 10.1021/acssynbio.8b00348

Abstract: The development of biosensors for in vitro quantification of small molecules such as metabolites or man-made chemicals is still a major challenge. Here we show that engineered variants of the sensory PAS domain of the… read more here.

Keywords: pas domain; histidine kinase; small molecules; structure based ... See more keywords

KidA, a multi-PAS domain protein, tunes the period of the cyanobacterial circadian oscillator

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recommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"

DOI: 10.1073/pnas.2202426119

Abstract: Significance Cyanobacteria have the simplest known circadian clock, but the mechanisms that connect the oscillator to cellular physiology are incompletely understood. We identify a previously unknown component of the circadian system, which we name KidA.… read more here.

Keywords: oscillator; pas; period; multi pas ... See more keywords

Neuronal PAS domain 1 identifies a major subpopulation of wakefulness-promoting GABAergic neurons in the basal forebrain

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recommendations! Published in 2024 at "Proceedings of the National Academy of Sciences of the United States of America"

DOI: 10.1073/pnas.2321410121

Abstract: Significance The basal forebrain (BF) is involved in control of sleep, cortical oscillations, attention, feeding, reward, and olfaction. Here, we characterize a major subset of BF GABAergic neurons which express neuronal PAS domain 1 (Npas1),… read more here.

Keywords: neuronal pas; basal forebrain; major subpopulation; pas domain ... See more keywords

Neuronal PAS domain protein 4 (Npas4) controls neuronal homeostasis in pentylenetetrazole‐induced epilepsy through the induction of Homer1a

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recommendations! Published in 2018 at "Journal of Neurochemistry"

DOI: 10.1111/jnc.14274

Abstract: Neuronal intrinsic homeostatic scaling‐down of excitatory synapse has been implicated in epilepsy pathogenesis to prevent the neuronal circuits from hyperexcitability. Recent findings suggest a role for neuronal PAS domain protein 4 (Npas4), an activity‐dependent neuron‐specific… read more here.

Keywords: pas domain; npas4; neuronal pas; npas4ko mice ... See more keywords

The BvgS PAS Domain, an Independent Sensory Perception Module in the Bordetella bronchiseptica BvgAS Phosphorelay

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recommendations! Published in 2019 at "Journal of Bacteriology"

DOI: 10.1128/jb.00286-19

Abstract: Despite high rates of vaccination, pertussis, a severe, highly contagious respiratory disease caused by the bacterium Bordetella pertussis, has reemerged as a significant health threat. In Bordetella pertussis and the closely related species Bordetella bronchiseptica,… read more here.

Keywords: pas domain; activity; bvgas; domain ... See more keywords

PAS Domain Protein Pas3 Interacts with the Chromatin Modifier Bre1 in Regulating Cryptococcal Morphogenesis

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recommendations! Published in 2018 at "mBio"

DOI: 10.1128/mbio.02135-18

Abstract: For the ubiquitous environmental pathogen Cryptococcus neoformans, the morphological transition from yeast to filament confers resistance to natural predators like soil amoeba and is an integral differentiation event to produce infectious spores. Interestingly, filamentation is… read more here.

Keywords: pas domain; domain protein; filamentation; chromatin modifier ... See more keywords

In vitro assessment of Neuronal PAS domain 2 mitigating compounds for scarless wound healing

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recommendations! Published in 2023 at "Frontiers in Medicine"

DOI: 10.3389/fmed.2022.1014763

Abstract: Background The core circadian gene Neuronal PAS domain 2 (NPAS2) is expressed in dermal fibroblasts and has been shown to play a critical role in regulating collagen synthesis during wound healing. We have performed high… read more here.

Keywords: collagen synthesis; neuronal pas; pas domain; wound healing ... See more keywords

Targeting neuronal PAS domain protein 2 and KN motif/ankyrin repeat domains 1: Advances in type 2 diabetes therapy

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recommendations! Published in 2024 at "World Journal of Diabetes"

DOI: 10.4239/wjd.v15.i11.2173

Abstract: This editorial summarizes the latest literature on the roles of neuronal PAS domain protein 2 and KN motif/ankyrin repeat domain 1 in type 2 diabetes (T2D). We highlight their involvement in β-cell dysfunction, explore their… read more here.

Keywords: neuronal pas; protein motif; domain protein; motif ankyrin ... See more keywords