Structure-Based Design of Versatile Biosensors for Small Molecules Based on the PAS Domain of a Thermophilic Histidine Kinase.
Sign Up to like & getrecommendations! Published in 2018 at "ACS synthetic biology"
DOI: 10.1021/acssynbio.8b00348
Abstract: The development of biosensors for in vitro quantification of small molecules such as metabolites or man-made chemicals is still a major challenge. Here we show that engineered variants of the sensory PAS domain of the… read more here.
Keywords: pas domain; histidine kinase; small molecules; structure based ... See more keywords
KidA, a multi-PAS domain protein, tunes the period of the cyanobacterial circadian oscillator
Sign Up to like & getrecommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2202426119
Abstract: Significance Cyanobacteria have the simplest known circadian clock, but the mechanisms that connect the oscillator to cellular physiology are incompletely understood. We identify a previously unknown component of the circadian system, which we name KidA.… read more here.
Keywords: oscillator; pas; period; multi pas ... See more keywords
Neuronal PAS domain protein 4 (Npas4) controls neuronal homeostasis in pentylenetetrazole‐induced epilepsy through the induction of Homer1a
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Neurochemistry"
DOI: 10.1111/jnc.14274
Abstract: Neuronal intrinsic homeostatic scaling‐down of excitatory synapse has been implicated in epilepsy pathogenesis to prevent the neuronal circuits from hyperexcitability. Recent findings suggest a role for neuronal PAS domain protein 4 (Npas4), an activity‐dependent neuron‐specific… read more here.
Keywords: pas domain; npas4; neuronal pas; npas4ko mice ... See more keywords
The BvgS PAS Domain, an Independent Sensory Perception Module in the Bordetella bronchiseptica BvgAS Phosphorelay
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Bacteriology"
DOI: 10.1128/jb.00286-19
Abstract: Despite high rates of vaccination, pertussis, a severe, highly contagious respiratory disease caused by the bacterium Bordetella pertussis, has reemerged as a significant health threat. In Bordetella pertussis and the closely related species Bordetella bronchiseptica,… read more here.
Keywords: pas domain; activity; bvgas; domain ... See more keywords
PAS Domain Protein Pas3 Interacts with the Chromatin Modifier Bre1 in Regulating Cryptococcal Morphogenesis
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DOI: 10.1128/mbio.02135-18
Abstract: For the ubiquitous environmental pathogen Cryptococcus neoformans, the morphological transition from yeast to filament confers resistance to natural predators like soil amoeba and is an integral differentiation event to produce infectious spores. Interestingly, filamentation is… read more here.
Keywords: pas domain; domain protein; filamentation; chromatin modifier ... See more keywords
In vitro assessment of Neuronal PAS domain 2 mitigating compounds for scarless wound healing
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Medicine"
DOI: 10.3389/fmed.2022.1014763
Abstract: Background The core circadian gene Neuronal PAS domain 2 (NPAS2) is expressed in dermal fibroblasts and has been shown to play a critical role in regulating collagen synthesis during wound healing. We have performed high… read more here.
Keywords: collagen synthesis; neuronal pas; pas domain; wound healing ... See more keywords