PASsing on Signals: PAS Kinase (PASK)-mTOR Signaling Conveys Nutrient Sufficiency Signals to Epigenetic (COMPASS) Complexes to Activate Stem Cell Differentiation Program (P15-009-19).
Sign Up to like & getrecommendations! Published in 2019 at "Current developments in nutrition"
DOI: 10.1093/cdn/nzz037.p15-009-19
Abstract: Objectives To determine how nutrient signaling impacts stem cell functions. Methods PASK phosphorylation: We measured in situ phosphorylation of PASK by metabolic 32P labeling of stem cells expressing WT or mutant versions of PASK. PASK… read more here.
Keywords: differentiation; stem cell; pask; stem ... See more keywords
The metabolic sensor PASK is a histone 3 kinase that also regulates H3K4 methylation by associating with H3K4 MLL2 methyltransferase complex
Sign Up to like & getrecommendations! Published in 2019 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkz786
Abstract: Abstract The metabolic sensor Per-Arnt-Sim (Pas) domain-containing serine/threonine kinase (PASK) is expressed predominantly in the cytoplasm of different cell types, although a small percentage is also expressed in the nucleus. Herein, we show that the… read more here.
Keywords: methylation; kinase; h3k4 mll2; pask ... See more keywords
Preventing Oxidative Stress in the Liver: An Opportunity for GLP-1 and/or PASK
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DOI: 10.3390/antiox10122028
Abstract: The liver’s high metabolic activity and detoxification functions generate reactive oxygen species, mainly through oxidative phosphorylation in the mitochondria of hepatocytes. In contrast, it also has a potent antioxidant mechanism for counterbalancing the oxidant’s effect… read more here.
Keywords: glp; pask preventing; pask; liver ... See more keywords
Storage and Utilization of Glycogen by Mouse Liver during Adaptation to Nutritional Changes Are GLP-1 and PASK Dependent
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DOI: 10.3390/nu13082552
Abstract: Glucagon-like peptide 1 (GLP-1) and PAS kinase (PASK) control glucose and energy homeostasis according to nutritional status. Thus, both glucose availability and GLP-1 lead to hepatic glycogen synthesis or degradation. We used a murine model… read more here.
Keywords: glycogen; pask; storage utilization; expression ... See more keywords
PASK links cellular energy metabolism with a mitotic self-renewal network to establish differentiation competence
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DOI: 10.7554/elife.81717
Abstract: Quiescent stem cells are activated in response to a mechanical or chemical injury to their tissue niche. Activated cells rapidly generate a heterogeneous progenitor population that regenerates the damaged tissues. While the transcriptional cadence that… read more here.
Keywords: differentiation competence; self renewal; metabolism; pask ... See more keywords