Apigenin attenuates pulmonary hypertension by inducing mitochondria-dependent apoptosis of PASMCs via inhibiting the hypoxia inducible factor 1α-KV1.5 channel pathway.
Sign Up to like & getrecommendations! Published in 2020 at "Chemico-biological interactions"
DOI: 10.1016/j.cbi.2020.108942
Abstract: Pulmonary hypertension (PH) is distal pulmonary arterial remodelling and is mainly due to the abnormal proliferation and apoptosis resistance of pulmonary artery smooth muscle cells (PASMCs). Apigenin, a natural dietary flavonoid, is a promising PH… read more here.
Keywords: pulmonary hypertension; pasmcs; apoptosis; mitochondria dependent ... See more keywords
Inhibition of RELM-β prevents hypoxia-induced overproliferation of human pulmonary artery smooth muscle cells by reversing PLC-mediated KCNK3 decline.
Sign Up to like & getrecommendations! Published in 2020 at "Life sciences"
DOI: 10.1016/j.lfs.2020.117419
Abstract: AIMS Although resistin-like molecule β (RELM-β) is involved in the pathological processes of various lung diseases, such as pulmonary inflammation, asthma and fibrosis, its potential roles in hypoxic pulmonary arterial hypertension (PAH) remain largely unknown.… read more here.
Keywords: protein; pasmcs; proliferation; relm ... See more keywords
Inhibition of phosphodiesterase-5 suppresses calcineurin/NFAT- mediated TRPC6 expression in pulmonary artery smooth muscle cells
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/s41598-017-06350-5
Abstract: The up-regulation of transient receptor potential channel 6 (TRPC6) has been found to contribute to the proliferation of pulmonary artery smooth muscle cells (PASMCs), and inhibition of phosphodiesterase-5 (PDE5) has been shown to suppress TRPC6… read more here.
Keywords: pasmcs; trpc6 expression; inhibition; expression ... See more keywords
A novel mechanism of sildenafil improving the excessive proliferation and H2S production in pulmonary arterial smooth muscle cells.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cardiovascular Pharmacology"
DOI: 10.1097/fjc.0000000000000714
Abstract: The dysregulation of pulmonary arterial vasoactive mediators or excessive proliferation of pulmonary arterial smooth muscle cells (PASMCs) might result in contraction or remodeling of pulmonary blood vessels, leading to related lung diseases. Recent studies suggest… read more here.
Keywords: cbs; pulmonary arterial; excessive proliferation; sildenafil ... See more keywords
Histone Methyl Transferase G9a/GLP—A Novel Avenue in Pulmonary Arterial Hypertension Treatment?
Sign Up to like & getrecommendations! Published in 2023 at "American Journal of Respiratory Cell and Molecular Biology"
DOI: 10.1165/rcmb.2023-0028ed
Abstract: Pulmonary arterial hypertension (PAH) is a rare but serious disease, with an estimated prevalence ranging from 10 to 52 cases per million (1). None of the currently available therapies has the ability to cure PAH,… read more here.
Keywords: pah; pasmcs; pulmonary arterial; g9a glp ... See more keywords
Crucial role of RAGE in inappropriate increase of smooth muscle cells from patients with pulmonary arterial hypertension
Sign Up to like & getrecommendations! Published in 2018 at "PLoS ONE"
DOI: 10.1371/journal.pone.0203046
Abstract: Background Pulmonary vascular remodeling of pulmonary arterial hypertension (PAH) is characterized by an inappropriate increase of vascular cells. The receptor for advanced glycation end products (RAGE) is a type I single-pass transmembrane protein belonging to… read more here.
Keywords: inappropriate increase; pasmcs; rage; pah ... See more keywords
Andrographolide Attenuates Established Pulmonary Hypertension via Rescue of Vascular Remodeling
Sign Up to like & getrecommendations! Published in 2021 at "Biomolecules"
DOI: 10.3390/biom11121801
Abstract: Pulmonary hypertension (PH) is characterized by vascular remodeling caused by marked proliferation of pulmonary artery smooth muscle cells (PASMCs). Andrographolide (ANDRO) is a potent anti-inflammatory agent which possesses antioxidant, and has anticarcinogenic activity. The present… read more here.
Keywords: andrographolide attenuates; pasmcs; vascular remodeling; pulmonary hypertension ... See more keywords
Smooth Muscle Phenotype in Idiopathic Pulmonary Hypertension: Hyper-Proliferative but not Cancerous
Sign Up to like & getrecommendations! Published in 2019 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms20143575
Abstract: Idiopathic pulmonary arterial hypertension (IPAH) is a complex disease associated with vascular remodeling and a proliferative disorder in pulmonary artery smooth muscle cells (PASMCs) that has been variably described as having neoplastic features. To decode… read more here.
Keywords: idiopathic pulmonary; pasmcs; smooth muscle; hypertension ... See more keywords