Comprehensive Evaluation of Metabolism and the Contribution of the Hepatic First-Pass Effect in the Bioavailability of Glabridin in Rats.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of agricultural and food chemistry"
DOI: 10.1021/acs.jafc.2c06460
Abstract: Glabridin is a bioactive isoflavan, which has a wide range of biological properties and is widely used in the market of health products and dietary supplements. However, the transformation pathway of glabridin in vivo is… read more here.
Keywords: glabridin rats; pass effect; glabridin; bioavailability ... See more keywords
First pass effect of mechanical thrombectomy for acute vertebrobasilar artery occlusion: data from the ANGEL-ACT registry
Sign Up to like & getrecommendations! Published in 2023 at "Journal of NeuroInterventional Surgery"
DOI: 10.1136/jnis-2023-020065
Abstract: Background To explore the incidence, predictors, and association of first pass effect (FPE) on clinical outcomes of mechanical thrombectomy (MT) for acute vertebrobasilar artery occlusion (VBAO) in the Asian population. Methods We selected patients from… read more here.
Keywords: effect; pass effect; icr; first pass ... See more keywords
Super large-bore ingestion of clot (SLIC) leads to high first pass effect in thrombectomy for large vessel occlusion
Sign Up to like & getrecommendations! Published in 2022 at "Journal of NeuroInterventional Surgery"
DOI: 10.1136/neurintsurg-2022-018806
Abstract: Background Super large-bore aspiration (SLBA) has shown high rates of complete clot ingestion. Objective To report the initial clinical feasibility, safety, and efficacy of this novel SLBA insert combination—super large-bore ingestion of clot (SLIC) technique… read more here.
Keywords: large bore; super large; catheter; pass effect ... See more keywords
Identifying the predictors of first-pass effect and its influence on clinical outcome in the setting of endovascular thrombectomy for acute ischemic stroke: Results from a multicentric prospective registry
Sign Up to like & getrecommendations! Published in 2020 at "International Journal of Stroke"
DOI: 10.1177/1747493020923051
Abstract: Background The first-pass effect, defined as a complete or near-complete recanalization after one pass (first-pass effect) of a mechanical thrombectomy device, has been related to better clinical outcome than good recanalization after more than one… read more here.
Keywords: predictors first; clinical outcome; first pass; pass effect ... See more keywords
First pass effect in posterior circulation occlusions: Analysis from the CICAT registry
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Stroke"
DOI: 10.1177/17474930221089772
Abstract: Background: The first pass effect (FPE) is an independent predictor of functional independence in patients with large vessel occlusion in anterior circulation ischemic strokes. However, whether it predicts outcome in posterior circulation large vessel occlusion… read more here.
Keywords: circulation; first pass; pass effect; functional independence ... See more keywords
First-Pass Effect Predicts Clinical Outcome and Infarct Growth After Thrombectomy for Distal Medium Vessel Occlusions
Sign Up to like & getrecommendations! Published in 2022 at "Neurosurgery"
DOI: 10.1227/neu.0000000000002129
Abstract: BACKGROUND: The first-pass effect in endovascular thrombectomy (EVT) has been associated with better clinical outcomes and decreased stroke progression in large vessel occlusion but has not been evaluated in distal, medium vessel occlusions (DMVOs). OBJECTIVE:… read more here.
Keywords: clinical outcome; first pass; pass effect;
First-pass effect of mechanical thrombectomy for anterior circulation large vessel occlusion: incidence, predictors, and clinical impact. Insight from the ANGEL-ACT registry.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of neurosurgery"
DOI: 10.3171/2023.1.jns222604
Abstract: OBJECTIVE The objective of this study was to investigate the incidence and predictors of first-pass effect (FPE) and to compare the clinical outcomes among FPE, multiple-pass effect, and incomplete reperfusion (ICR) in acute anterior circulation… read more here.
Keywords: occlusion; pass effect; fpe; fpe aor ... See more keywords
In Vitro Analysis of the Efficacy of Endovascular Thrombectomy Techniques according to the Vascular Tortuosity Using 3D Printed Models
Sign Up to like & getrecommendations! Published in 2022 at "American Journal of Neuroradiology"
DOI: 10.3174/ajnr.a7633
Abstract: BACKGROUND AND PURPOSE: Achieving complete recanalization with the front-line endovascular thrombectomy device improves the outcome of acute stroke. The aim of this study was to evaluate whether various thrombectomy techniques including contact aspiration, stent retriever… read more here.
Keywords: pass effect; distal emboli; thrombectomy; first pass ... See more keywords
Predictors of First-Pass Effect in Endovascular Thrombectomy With Stent-Retriever Devices for Acute Large Vessel Occlusion Stroke
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Neurology"
DOI: 10.3389/fneur.2022.664140
Abstract: Background and Purpose Successful recanalization after the first pass of the device in endovascular thrombectomy (EVT) can significantly improve patients' prognosis. We aimed to investigate the possible factors that influence achieving the first-pass effect (FPE).… read more here.
Keywords: large vessel; pass effect; occlusion; endovascular thrombectomy ... See more keywords
First Pass Effect and Location of Occlusion in Recanalized MCA M1 Occlusions
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Neurology"
DOI: 10.3389/fneur.2022.884235
Abstract: Background The first pass effect has been shown to improve clinical outcomes in patients with middle cerebral artery (MCA) M1 occlusions. Objective To determine the rates of first pass effect in MCA M1 occlusions and… read more here.
Keywords: pass effect; effect; location; occlusion ... See more keywords
Comparable Intestinal and Hepatic First-Pass Effect of YL-IPA08 on the Bioavailability and Effective Brain Exposure, a Rapid Anti-PTSD and Anti-Depression Compound
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2020.588127
Abstract: YL-IPA08, exerting rapid antidepressant-like and anxiolytic-like effects on behaviors by translocator protein (TSPO) mediation, is a novel compound that has been discovered and developed at our institute. Fit-for-purpose pharmacokinetic properties is urgently needed to be… read more here.
Keywords: ipa08 bioavailability; bioavailability; pass effect; ipa08 ... See more keywords