117 The Impact of Cell Passage Number on Elucidating Toxicological Mechanisms in Vitro
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DOI: 10.1093/annweh/wxac087.208
Abstract: Cell passage number is of high importance in experimental design and can cause biochemical, genetic, and/or morphological changes to a cell. This project aimed to understand the impact of increasing cell passage number on the… read more here.
Keywords: passage number; cell; impact; passage ... See more keywords
Functional characterization of a bovine luteal cell culture model: Effects of passage number
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DOI: 10.1371/journal.pone.0334047
Abstract: Primary cell culture models are useful tools to analyze intracellular signaling pathways and interactions in detail. However, at higher passages, vital cell characteristics such as cell morphology, physiology, gene expression and cell proliferation can be… read more here.
Keywords: luteal cells; passage number; cell; culture ... See more keywords
Downregulation of activin-signaling gene expression in passaged normal human dermal fibroblasts.
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DOI: 10.3892/br.2019.1258
Abstract: Activins are members of the transforming growth factor-β (TGF-β) superfamily and play important roles in proliferation, differentiation, and apoptosis of various target cells. We investigated changes of activin, activin receptor (ActR), and Smad-signaling gene expression… read more here.
Keywords: human dermal; passage number; expression; normal human ... See more keywords