Vaccines Targeting PCSK9: A Promising Alternative to Passive Immunization with Monoclonal Antibodies in the Management of Hyperlipidaemia?
Sign Up to like & getrecommendations! Published in 2018 at "Drugs"
DOI: 10.1007/s40265-018-0915-5
Abstract: Hypercholesterolaemia is frequently observed in patients with cardiovascular diseases (CVD) and is associated with increased mortality. Statin treatment has been the standard of care for reducing low-density lipoprotein cholesterol (LDL-C) to improve cardiovascular outcomes. However,… read more here.
Keywords: monoclonal antibodies; vaccines targeting; targeting pcsk9; pcsk9 ... See more keywords
Simplified monomeric VHH-Fc antibodies provide new opportunities for passive immunization.
Sign Up to like & getrecommendations! Published in 2019 at "Current opinion in biotechnology"
DOI: 10.1016/j.copbio.2019.11.006
Abstract: Simplified monomeric monoclonal antibodies consisting of a single-domain VHH, derived from camelid heavy-chain only antibodies, fused with the Fc domain of either IgG (VHH-IgG) or IgA (VHH-IgA) antibodies, are promising therapeutic proteins. These simplified single-gene… read more here.
Keywords: vhh antibodies; monomeric vhh; simplified monomeric; vhh ... See more keywords
Passive immunization against inhibin increases testicular blood flow in male goats.
Sign Up to like & getrecommendations! Published in 2020 at "Theriogenology"
DOI: 10.1016/j.theriogenology.2019.12.022
Abstract: The present study investigated whether or not passive immunization against inhibin modulates testicular blood flow in goats. Male Shiba goats were injected with either 10 ml of inhibin antiserum (INH group; n = 5) or 10 ml of normal… read more here.
Keywords: blood flow; passive immunization; group; inh group ... See more keywords
Egg Yolk Antibody for Passive Immunization: Status, Challenges, and Prospects.
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DOI: 10.1021/acs.jafc.2c09180
Abstract: The immunoglobulin Y (IgY) derived from hyperimmune egg yolk is a promising passive immune agent to combat microbial infections in humans and livestock. Numerous studies have been performed to develop specific egg yolk IgY for… read more here.
Keywords: egg yolk; passive immunization; egg; yolk igy ... See more keywords
Oral Passive Immunization With Plasma-Derived Polyreactive Secretory-Like IgA/M Partially Protects Mice Against Experimental Salmonellosis
Sign Up to like & getrecommendations! Published in 2018 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2018.02970
Abstract: Secretory immunoglobulins have a critical role in defense of the gastrointestinal tract and are known to act by preventing bacterial acquisition. A stringent murine model of bacterial infection with Salmonella enterica Typhimurium was used to… read more here.
Keywords: secretory; oral passive; passive immunization; plasma derived ... See more keywords
Passive Immunization in Alpha-Synuclein Preclinical Animal Models
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DOI: 10.3390/biom12020168
Abstract: Alpha-synucleinopathies include Parkinson’s disease, dementia with Lewy bodies, pure autonomic failure and multiple system atrophy. These are all progressive neurodegenerative diseases that are characterized by pathological misfolding and accumulation of the protein alpha-synuclein (αsyn) in… read more here.
Keywords: passive immunization; animal models; alpha synuclein; motor ... See more keywords
Active and Passive Immunization with an Anti-Methamphetamine Vaccine Attenuates the Behavioral and Cardiovascular Effects of Methamphetamine
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DOI: 10.3390/vaccines10091508
Abstract: Background: Methamphetamine use disorder (MUD) is a growing health concern with no FDA-approved treatment. The present series of studies build upon our previous work developing an anti-methamphetamine (MA) vaccine for MUD. We determined the effects… read more here.
Keywords: passive immunization; cardiovascular effects; anti methamphetamine; methamphetamine vaccine ... See more keywords
Antibodies to SARS-CoV-2 and their potential for therapeutic passive immunization
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DOI: 10.7554/elife.57877
Abstract: We review aspects of the antibody response to SARS-CoV-2, the causative agent of the COVID-19 pandemic. The topics we cover are relevant to immunotherapy with plasma from recovered patients, monoclonal antibodies against the viral S-protein,… read more here.
Keywords: potential therapeutic; passive immunization; antibodies sars; therapeutic passive ... See more keywords