LAUSR

About LAUSR
Donate
Contact Us

Follow us:

You are not signed in:

Sign Up!


   Articles with "pat1" as a keyword



Glycosylation affects the stability and subcellular distribution of human PAT1 protein

Sign Up to like & get
recommendations! Published in 2017 at "FEBS Letters"

DOI: 10.1002/1873-3468.12567

Abstract: The amino acid transporter PAT1 is typically expressed on the lysosome and plasma membranes in various human tissues. Glycosylation has been shown to be critical for the cell surface expression of PAT1, but not for… read more here.

Keywords: glycosylation affects; subcellular distribution; affects stability; stability ... See more keywords

The amino acid transporter PAT1 regulates mTORC1 in a nutrient-sensitive manner that requires its transport activity.

Sign Up to like & get
recommendations! Published in 2019 at "Cellular signalling"

DOI: 10.1016/j.cellsig.2018.09.017

Abstract: The proton-coupled amino acid transporter PAT1 has been postulated to regulate the amino acid-stimulated mTORC1 through two different mechanisms, either it activates mTORC1 by sensing and transducing the lysosomal amino acid signal to mTORC1, or… read more here.

Keywords: amino acid; acid transporter; mtorc1; pat1 ... See more keywords

A Direct Link Implicating Loss of SLC26A6 to Gut Microbial Dysbiosis, Compromised Barrier Integrity and Inflammation.

Sign Up to like & get
recommendations! Published in 2024 at "Gastroenterology"

DOI: 10.1053/j.gastro.2024.05.002

Abstract: BACKGROUND Putative anion transporter-1 (PAT1, SLC26A6) plays a key role in intestinal oxalate and bicarbonate secretion. PAT1 knockout (PKO) mice exhibit hyperoxaluria and nephrolithiasis. Notably, diseases such as inflammatory bowel diseases (IBD) are also associated… read more here.

Keywords: loss; pat1; integrity; inflammation ... See more keywords

SLC26A6 Deficiency Differentially Alters the Expression of MicroRNAs and RNA Binding Proteins in the Intestine

Sign Up to like & get
recommendations! Published in 2024 at "Physiology"

DOI: 10.1152/physiol.2024.39.s1.779

Abstract: BACKGROUND: Putative anion transporter 1 (PAT1, SLC26A6), expressed at the luminal membrane of the intestinal epithelial cells, plays a key role in oxalate homeostasis and bicarbonate secretion. Additionally, we have recently shown that PAT1 knockout… read more here.

Keywords: physiology; pat1; binding proteins; expression ... See more keywords

Pat1 increases the range of decay factors and RNA bound by the Lsm1-7 complex.

Sign Up to like & get
recommendations! Published in 2020 at "RNA"

DOI: 10.1261/rna.075812.120

Abstract: Pat1 promotes the activation and assembly of multiple proteins during mRNA decay. After deadenylation, the Pat1/Lsm1-7 complex binds to transcripts containing oligo(A) tails, which can be modified by the addition of several terminal uridine residues.… read more here.

Keywords: decay factors; lsm1 complex; lsm1 binding; lsm1 ... See more keywords