Cathepsin B and L inhibitors: a patent review (2010 - present)
Sign Up to like & getrecommendations! Published in 2017 at "Expert Opinion on Therapeutic Patents"
DOI: 10.1080/13543776.2017.1272572
Abstract: ABSTRACT Introduction: Cathepsins play an important role in protein degradation and processing. Aberrant cathepsin B or L is closely associated with many serious diseases such as cancer, osteoporosis and autoimmune disorders. Therefore, development of potent… read more here.
Keywords: patent review; cathepsin; inhibitors patent; 2010 present ... See more keywords
MAO inhibitors and their wider applications: a patent review
Sign Up to like & getrecommendations! Published in 2018 at "Expert Opinion on Therapeutic Patents"
DOI: 10.1080/13543776.2018.1427735
Abstract: ABSTRACT Introduction: Monoamine oxidase (MAO) inhibitors, after the initial ‘golden age’, are currently used as third-line antidepressants (selective MAO-A inhibitors) or clinically enrolled as co-adjuvants for neurodegenerative diseases (selective MAO-B inhibitors). However, the research within… read more here.
Keywords: inhibitors wider; patent review; applications patent; mao ... See more keywords
A patent review of butyrylcholinesterase inhibitors and reactivators 2010–2017
Sign Up to like & getrecommendations! Published in 2018 at "Expert Opinion on Therapeutic Patents"
DOI: 10.1080/13543776.2018.1476494
Abstract: ABSTRACT Introduction: Butyrylcholinesterase (BuChE) has obtained a renewed interest as therapeutic target in Alzheimer’s disease (AD), when changes in BuChE activity and expression along disease progression were highlighted as well as correlation between BuChE levels… read more here.
Keywords: patent review; butyrylcholinesterase; buche inhibitors; buche ... See more keywords
Pharmacological applications of farnesol (C15H26O): a patent review
Sign Up to like & getrecommendations! Published in 2020 at "Expert Opinion on Therapeutic Patents"
DOI: 10.1080/13543776.2020.1718653
Abstract: ABSTRACT Introduction: Farnesol (C15H26O) is a sesquiterpene alcohol found in essential oils. This substance is reported to have different pharmacological activities such as antimicrobial, antitumor and antioxidant effects, as well as actions in different body… read more here.
Keywords: patent review; farnesol c15h26o; pharmacological applications; c15h26o patent ... See more keywords
A patent review of apelin receptor (APJR) modulators (2014-2019)
Sign Up to like & getrecommendations! Published in 2020 at "Expert Opinion on Therapeutic Patents"
DOI: 10.1080/13543776.2020.1731473
Abstract: ABSTRACT Introduction: The apelinergic system is regarded as a novel therapeutic target for cardiovascular health, fluid homeostasis, the hypothalamic-pituitary-adrenal (HPA) axis as well as carbohydrate and fat metabolism. Two endogenous peptide ligands, namely apelin and… read more here.
Keywords: patent review; small molecule; 2014 2019; apjr ... See more keywords
An updated patent review of VEGFR-2 inhibitors (2017-present)
Sign Up to like & getrecommendations! Published in 2021 at "Expert Opinion on Therapeutic Patents"
DOI: 10.1080/13543776.2021.1935872
Abstract: ABSTRACT Introduction: Angiogenesis is a vital process for cellular functions in both physiological and pathophysiological conditions and is one of the hallmarks of cancer progression and metastasis. VEGF/VEGFR-2 signaling pathway has been recognized as the… read more here.
Keywords: patent review; review vegfr; updated patent; vegfr inhibitors ... See more keywords
A patent review of MALT1 inhibitors (2013-present).
Sign Up to like & getrecommendations! Published in 2021 at "Expert opinion on therapeutic patents"
DOI: 10.1080/13543776.2021.1951703
Abstract: INTRODUCTION MALT1 is the only human paracaspase, a protease with unique cleavage activity and substrate specificity. As a key regulator of immune responses, MALT1 has attracted attention as an immune modulatory target for the treatment… read more here.
Keywords: patent review; review malt1; malt1; inhibitors 2013 ... See more keywords
A patent review of berberine and its derivatives with various pharmacological activities (2016-2020).
Sign Up to like & getrecommendations! Published in 2021 at "Expert opinion on therapeutic patents"
DOI: 10.1080/13543776.2021.1974001
Abstract: INTRODUCTION Berberine (BBR), as one of the outstanding representatives of isoquinoline alkaloids, has been used as an antibacterial drug for a long time in China since ancient times. Currently, a large number of studies have… read more here.
Keywords: patent review; pharmacological activities; berberine derivatives; 2016 2020 ... See more keywords
A patent review of pharmaceutical and therapeutic applications of oxadiazole derivatives for the treatment of chronic diseases (2013–2021)
Sign Up to like & getrecommendations! Published in 2022 at "Expert Opinion on Therapeutic Patents"
DOI: 10.1080/13543776.2022.2116312
Abstract: ABSTRACT Introduction Oxadiazole is a unique class of heterocycle, possessing numerous important biomedical and therapeutic applications, such as anti-bacterial, anti-cancer, anti-inflammatory, inhibitors for diverse enzymes, receptor modulators, and neuroprotective properties. The rapid development in the… read more here.
Keywords: receptor agonists; applications oxadiazole; patent review; 2013 2021 ... See more keywords
An updated patent review of glutaminase inhibitors (2019–2022)
Sign Up to like & getrecommendations! Published in 2023 at "Expert Opinion on Therapeutic Patents"
DOI: 10.1080/13543776.2023.2173573
Abstract: ABSTRACT Introduction Kidney-type glutaminase (GLS1), a key enzyme controlling the hydrolysis of glutamine to glutamate to resolve the ‘glutamine addiction’ of cancer cells, has been shown to play a central role in supporting cancer growth… read more here.
Keywords: gls1; gls1 inhibitors; updated patent; patent review ... See more keywords
An updated patent review of Nrf2 activators (2020-present)
Sign Up to like & getrecommendations! Published in 2023 at "Expert Opinion on Therapeutic Patents"
DOI: 10.1080/13543776.2023.2178299
Abstract: ABSTRACT Introduction The nuclear factor erythroid 2-related factor 2 (Nrf2) is a pivotal transcription factor that controls the expression of numerous cytoprotective genes and regulates cellular defense system against oxidative insults. Thus, activating the Nrf2… read more here.
Keywords: updated patent; patent review; nrf2 activators; activators 2020 ... See more keywords