Paternal obesity induces placental hypoxia and sex-specific impairments in placental vascularization and offspring metabolism
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DOI: 10.1093/biolre/ioac066
Abstract: Abstract Paternal obesity predisposes offspring to metabolic dysfunction, but the underlying mechanisms remain unclear. We investigated whether this metabolic dysfunction is associated with changes in placental vascular development and is fueled by endoplasmic reticulum (ER)… read more here.
Keywords: obesity induces; placental hypoxia; paternal obesity; sex specific ... See more keywords
Intergenerational Influence of Paternal Obesity on Metabolic and Reproductive Health Parameters of the Offspring: Male-Preferential Impact and Involvement of Kiss1-Mediated Pathways
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DOI: 10.1210/en.2017-00705
Abstract: Obesity and its comorbidities are reaching epidemic proportions worldwide. Maternal obesity is known to predispose the offspring to metabolic disorders, independently of genetic inheritance. This intergenerational transmission has also been suggested for paternal obesity, with… read more here.
Keywords: metabolic reproductive; impact; reproductive health; paternal obesity ... See more keywords
Paternal obesity and its transgenerational effects on gastrointestinal function in male rat offspring
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DOI: 10.1590/1414-431x2020e11116
Abstract: The interplay between obesity and gastrointestinal (GI) motility is contradictory, and the transgenerational influence on this parameter is unknown. We aimed to evaluate the GI function in a model of paternal obesity and two subsequent… read more here.
Keywords: male; obesity; paternal obesity; male offspring ... See more keywords
Effects of Paternal Obesity on Fetal Development and Pregnancy Complications: A Prospective Clinical Cohort Study
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DOI: 10.3389/fendo.2022.826665
Abstract: Objectives To evaluate the association between paternal obesity and fetal development and pregnancy complications. Study Design This prospective cohort clinical trial analyzed data from 7683 women with singleton pregnancies. All study subjects were sequentially divided… read more here.
Keywords: development; paternal obesity; pregnancy complications; obesity ... See more keywords