Nonparametric Path‐Specific Effects on a Survival Outcome Through Multiple Time‐to‐Event Mediators
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DOI: 10.1002/sim.10327
Abstract: A causal mediation model with multiple time‐to‐event mediators is exemplified by the natural course of human disease marked by sequential milestones with a time‐to‐event nature. For example, from hepatitis B infection to death, patients may… read more here.
Keywords: event mediators; path specific; time event; event ... See more keywords
A mediation analysis for a nonrare dichotomous outcome with sequentially ordered multiple mediators.
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DOI: 10.1002/sim.8485
Abstract: Mediation analyses can help us to understand the biological mechanism in which an exposure or treatment affects an outcome. Single mediator analyses have been used in various applications, but may not be appropriate for analyzing… read more here.
Keywords: outcome; mediation; path specific; sequentially ordered ... See more keywords
Quantifying an Adherence Path-Specific Effect of Antiretroviral Therapy in the Nigeria PEPFAR Program
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DOI: 10.1080/01621459.2017.1295862
Abstract: ABSTRACT Since the early 2000s, evidence has accumulated for a significant differential effect of first-line antiretroviral therapy (ART) regimens on human immunodeficiency virus (HIV) viral load suppression. This finding was replicated in our data from… read more here.
Keywords: antiretroviral therapy; pepfar program; path specific; effect ... See more keywords
On the Conventional Definition of Path-specific Effects: Fully Mediated Interaction With Multiple Ordered Mediators.
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DOI: 10.1097/ede.0000000000001520
Abstract: Path-specific effects are a critical measure for assessing mediation in the presence of multiple mediators. However, the conventional definition of path-specific effects has generated controversy because it often causes misinterpretation of the results of multiple… read more here.
Keywords: fully mediated; specific effects; mediated interaction; path specific ... See more keywords
Path-specific effects in the presence of a survival outcome and causally ordered multiple mediators with application to genomic data
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DOI: 10.1177/09622802221104239
Abstract: Causal multimediation analysis (i.e. the causal mediation analysis with multiple mediators) is critical for understanding the effectiveness of interventions, especially in medical research. Deriving the path-specific effects of exposure on the outcome through a set… read more here.
Keywords: multiple mediators; outcome; path specific; path ... See more keywords
Complete effect decomposition for an arbitrary number of multiple ordered mediators with time-varying confounders: A method for generalized causal multi-mediation analysis
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DOI: 10.1177/09622802221130580
Abstract: Causal mediation analysis is advantageous for mechanism investigation. In settings with multiple causally ordered mediators, path-specific effects have been introduced to specify the effects of certain combinations of mediators. However, most path-specific effects are unidentifiable.… read more here.
Keywords: ordered mediators; path specific; mediation analysis; number ... See more keywords