Understanding the Pathobiology of Pulmonary Hypertension Due to Left Heart Disease
Sign Up to like & getrecommendations! Published in 2022 at "Circulation Research"
DOI: 10.1161/circresaha.122.319967
Abstract: The development of pulmonary hypertension (PH) is common and has adverse prognostic implications in patients with heart failure due to left heart disease (LHD), and thus far, there are no known treatments specifically for PH-LHD,… read more here.
Keywords: pulmonary hypertension; hypertension; disease; pathobiology ... See more keywords
Estrogen Receptors and Signaling in Fibroids: Role in Pathobiology and Therapeutic Implications
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DOI: 10.1177/1933719116678686
Abstract: Uterine fibroids are the most common gynecologic tumors with a significant medical and financial burden. Several genetic, hormonal, and biological factors have been shown to contribute to the development and growth of fibroid tumors. Of… read more here.
Keywords: receptors signaling; signaling fibroids; kinase; pathobiology ... See more keywords
Allergen inhalation generates pro-inflammatory oxidised phosphatidylcholine associated with airway dysfunction
Sign Up to like & getrecommendations! Published in 2020 at "European Respiratory Journal"
DOI: 10.1183/13993003.00839-2020
Abstract: Oxidised phosphatidylcholines (OxPCs) are produced under conditions of elevated oxidative stress and can contribute to human disease pathobiology. However, their role in allergic asthma is unexplored. The aim of this study was to characterise the… read more here.
Keywords: pathobiology; inflammatory; asthma; airway dysfunction ... See more keywords
The Complexity of Secondary Cascade Consequent to Traumatic Brain Injury: Pathobiology and Potential Treatments.
Sign Up to like & getrecommendations! Published in 2021 at "Current neuropharmacology"
DOI: 10.2174/1570159x19666210215123914
Abstract: According to the World Health Organization, Traumatic brain injury (TBI) is the major cause of death and disability and will surpass the other diseases by the year 2020. Patients who suffer TBI face many difficulties… read more here.
Keywords: traumatic brain; brain injury; complexity secondary; injury ... See more keywords
Proteomics analysis of the p.G849D variant in neurexin 2 alpha may reveal insight into Parkinson’s disease pathobiology
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Aging Neuroscience"
DOI: 10.3389/fnagi.2022.1002777
Abstract: Parkinson’s disease (PD), the fastest-growing neurological disorder globally, has a complex etiology. A previous study by our group identified the p.G849D variant in neurexin 2 (NRXN2), encoding the synaptic protein, NRXN2α, as a possible causal… read more here.
Keywords: disease; may reveal; variant neurexin; parkinson disease ... See more keywords
Proteomics and Phosphoproteomics of Circulating Extracellular Vesicles Provide New Insights into Diabetes Pathobiology
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms23105779
Abstract: The purpose of this study was to define the proteomic and phosphoproteomic landscape of circulating extracellular vesicles (EVs) in people with normal glucose tolerance (NGT), prediabetes (PDM), and diabetes (T2DM). Archived serum samples from 30… read more here.
Keywords: extracellular vesicles; pdm t2dm; phosphoproteomics circulating; pathobiology ... See more keywords
Aspergillus Endophthalmitis: Epidemiology, Pathobiology, and Current Treatments
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Fungi"
DOI: 10.3390/jof8070656
Abstract: Fungal endophthalmitis is one of the leading causes of vision loss worldwide. Post-operative and traumatic injuries are major contributing factors resulting in ocular fungal infections in healthy and, more importantly, immunocompromised individuals. Among the fungal… read more here.
Keywords: fungal endophthalmitis; endophthalmitis; aspergillus endophthalmitis; pathobiology ... See more keywords