ATP functions as a pathogen-associated molecular pattern to activate the E3 ubiquitin ligase RNF213
Sign Up to like & getrecommendations! Published in 2025 at "Nature Communications"
DOI: 10.1038/s41467-025-59444-4
Abstract: The giant E3 ubiquitin ligase RNF213 is a conserved component of mammalian cell-autonomous immunity, limiting the replication of bacteria, viruses and parasites. To understand how RNF213 reacts to these unrelated pathogens, we employ chemical and… read more here.
Keywords: pathogen associated; ubiquitin ligase; ligase rnf213; associated molecular ... See more keywords
BACTERIAL PATHOGEN–ASSOCIATED MOLECULAR PATTERNS UPREGULATE HUMAN GLUCOCORTICOID RECEPTOR EXPRESSION IN PERIPHERAL BLOOD MONONUCLEAR CELLS
Sign Up to like & getrecommendations! Published in 2022 at "Shock"
DOI: 10.1097/shk.0000000000002004
Abstract: ABSTRACT It is well known that bacterial components (pathogen-associated molecular patterns [PAMPs]) induce a proinflammatory response through pattern recognition receptor signaling. What is not known, however, is how the inflammatory response is downregulated. We hypothesize… read more here.
Keywords: molecular patterns; expression; hgr; associated molecular ... See more keywords
Pathogen-associated grooming.
Sign Up to like & getrecommendations! Published in 2023 at "Science signaling"
DOI: 10.1126/scisignal.adg9431
Abstract: A fungal surface protein elicits grooming in flies. read more here.
Keywords: associated grooming; pathogen associated;
Nature of β-1,3-Glucan-Exposing Features on Candida albicans Cell Wall and Their Modulation
Sign Up to like & getrecommendations! Published in 2022 at "mBio"
DOI: 10.1128/mbio.02605-22
Abstract: Microbes that coexist with humans have evolved ways of avoiding or evading our immunological defenses. These include the masking by these microbes of their “pathogen-associated molecular patterns” (PAMPs), which are recognized as “foreign” and used… read more here.
Keywords: cell; cell wall; candida albicans; pathogen associated ... See more keywords
Suppression of CYP1 members of the AHR response by pathogen‐associated molecular patterns
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Leukocyte Biology"
DOI: 10.1189/jlb.4a0617-218rr
Abstract: The aryl hydrocarbon receptor (AHR) is a ligand‐activated transcription factor that triggers a broad response, which includes the regulation of proinflammatory cytokine production by monocytes and macrophages. AHR is negatively regulated by a set of… read more here.
Keywords: pathogen associated; ahr response; associated molecular; response ... See more keywords
Miniature chicken ileal explant culture to investigate the inflammatory response induced by pathogen-associated molecular patterns
Sign Up to like & getrecommendations! Published in 2025 at "Frontiers in Veterinary Science"
DOI: 10.3389/fvets.2025.1484333
Abstract: Gastrointestinal inflammation leads to maldigestion and systemic diseases in poultry. To tackle the problem of the industry and to search for therapeutic candidates in vitro models are inevitable. Both immersion and air-liquid interface explant models… read more here.
Keywords: molecular patterns; miniature chicken; culture; pathogen associated ... See more keywords
Protective Effects of Fucoxanthin Dampen Pathogen-Associated Molecular Pattern (PAMP) Lipopolysaccharide-Induced Inflammatory Action and Elevated Intraocular Pressure by Activating Nrf2 Signaling and Generating Reactive Oxygen Species
Sign Up to like & getrecommendations! Published in 2021 at "Antioxidants"
DOI: 10.3390/antiox10071092
Abstract: Inflammation and oxidative stress are closely related processes in the pathogenesis of various ocular diseases. Uveitis is a disorder of the uvea and ocular tissues that causes extreme pain, decreases visual acuity, and can eventually… read more here.
Keywords: pattern pamp; pathogen associated; associated molecular; effects fucoxanthin ... See more keywords
Helicobacter pylori Pathogen-Associated Molecular Patterns: Friends or Foes?
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms23073531
Abstract: Microbial infections are sensed by the host immune system by recognizing signature molecules called Pathogen-Associated Molecular Patterns—PAMPs. The binding of these biomolecules to innate immune receptors, called Pattern Recognition Receptors (PRRs), alerts the host cell,… read more here.
Keywords: pathogen; molecular patterns; associated molecular; host ... See more keywords
Fungal α-1,3-Glucan as a New Pathogen-Associated Molecular Pattern in the Insect Model Host Galleria mellonella
Sign Up to like & getrecommendations! Published in 2021 at "Molecules"
DOI: 10.3390/molecules26165097
Abstract: Recognition of pathogen-associated molecular patterns (PAMPs) by appropriate pattern recognition receptors (PRRs) is a key step in activating the host immune response. The role of a fungal PAMP is attributed to β-1,3-glucan. The role of… read more here.
Keywords: pathogen associated; associated molecular; response; galleria mellonella ... See more keywords