Unpacking the Pathogen Box—An Open Source Tool for Fighting Neglected Tropical Disease
Sign Up to like & getrecommendations! Published in 2019 at "ChemMedChem"
DOI: 10.1002/cmdc.201800755
Abstract: The Pathogen Box is a 400‐strong collection of drug‐like compounds, selected for their potential against several of the world's most important neglected tropical diseases, including trypanosomiasis, leishmaniasis, cryptosporidiosis, toxoplasmosis, filariasis, schistosomiasis, dengue virus and trichuriasis,… read more here.
Keywords: pathogen; drug; pathogen box; open source ... See more keywords
Screening and Identification of Pathogen Box® Compounds with anti-Trypanosoma evansi Activity.
Sign Up to like & getrecommendations! Published in 2020 at "Acta tropica"
DOI: 10.1016/j.actatropica.2020.105421
Abstract: The development of new drugs targeting neglected animal diseases is imperative. In Asia and South America, Trypanosoma evansi is a pathogen that affects horses and other species, causing economic losses associated with reduced animal productivity… read more here.
Keywords: evansi; activity; pathogen box; evansi activity ... See more keywords
Discovery of a Novel Antifungal Agent in the Pathogen Box
Sign Up to like & getrecommendations! Published in 2017 at "mSphere"
DOI: 10.1128/msphere.00120-17
Abstract: Cryptococcus neoformans and Candida albicans are two major human fungal pathogens and together account for over 1.4 million infections annually, with very high mortality rates. These fungi often infect immunocompromised individuals, such as HIV/AIDS patients.… read more here.
Keywords: pathogen; fungal pathogens; million infections; compound ... See more keywords
Screening of the Pathogen Box for inhibitors with dual efficacy against Giardia lamblia and Cryptosporidium parvum
Sign Up to like & getrecommendations! Published in 2018 at "PLoS Neglected Tropical Diseases"
DOI: 10.1371/journal.pntd.0006673
Abstract: There is need for a more efficient cell-based assay amenable to high-throughput drug screening against Giardia lamblia. Here, we report the development of a screening method utilizing G. lamblia engineered to express red-shifted firefly luciferase.… read more here.
Keywords: pathogen; inhibition; pathogen box; giardia lamblia ... See more keywords
Identification of two potential inhibitors of Sporothrix brasiliensis and Sporothrix schenckii in the Pathogen Box collection
Sign Up to like & getrecommendations! Published in 2020 at "PLoS ONE"
DOI: 10.1371/journal.pone.0240658
Abstract: Sporotrichosis is a neglected endemic mycosis with a high incidence in Latin America, mainly in Brazil. Sporothrix schenckii is the most frequent species in Latin America, whereas Sporothrix brasiliensis is the predominant species observed in… read more here.
Keywords: brasiliensis; sporothrix brasiliensis; pathogen box; sporothrix schenckii ... See more keywords
Screening the Pathogen Box to Discover and Characterize New Cruzain and TbrCatL Inhibitors
Sign Up to like & getrecommendations! Published in 2023 at "Pathogens"
DOI: 10.3390/pathogens12020251
Abstract: Chagas disease and Human African Trypanosomiasis, caused by Trypanosoma cruzi and T. brucei, respectively, pose relevant health challenges throughout the world, placing 65 to 70 million people at risk each. Given the limited efficacy and… read more here.
Keywords: cruzain; pathogen box; cruzain tbrcatl; screening pathogen ... See more keywords