Structure‐guided stabilization of pathogen‐derived peptide‐HLA‐E complexes using non‐natural amino acids conserves native TCR recognition
Sign Up to like & getrecommendations! Published in 2022 at "European Journal of Immunology"
DOI: 10.1002/eji.202149745
Abstract: The nonpolymorphic class Ib molecule, HLA‐E, primarily presents peptides from HLA class Ia leader peptides, providing an inhibitory signal to NK cells via CD94/NKG2 interactions. read more here.
Keywords: derived peptide; stabilization pathogen; peptide hla; pathogen derived ... See more keywords
Deep Learning-Enabled Raman Spectroscopic Identification of Pathogen-Derived Extracellular Vesicles and the Biogenesis Process.
Sign Up to like & getrecommendations! Published in 2022 at "Analytical chemistry"
DOI: 10.1021/acs.analchem.2c02226
Abstract: Pathogenic bacterial infections, exacerbated by increasing antimicrobial resistance, pose a major threat to human health worldwide. Extracellular vesicles (EVs), secreted by bacteria and acting as their "long-distance weapons", play an important role in the occurrence… read more here.
Keywords: extracellular vesicles; spectroscopy; biogenesis process; pathogen derived ... See more keywords
Assay design for unambiguous identification and quantification of circulating pathogen-derived peptide biomarkers
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DOI: 10.7150/thno.70373
Abstract: Rationale: Circulating pathogen-derived proteins can serve as useful biomarkers for infections but may be detected with poor sensitivity and specificity by standard immunoassays due to masking effects and cross-reactivity. Mass spectrometry (MS)-read immunoassays for biomarker-derived… read more here.
Keywords: tuberculosis; disease; circulating pathogen; pathogen derived ... See more keywords