A loss‐of‐function mutation p.T256M in NDRG4 is implicated in the pathogenesis of pulmonary atresia with ventricular septal defect (PA/VSD) and tetralogy of Fallot (TOF)
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DOI: 10.1002/2211-5463.13044
Abstract: Pulmonary atresia with ventricular septal defect (PA/VSD) is a rare congenital heart disease (CHD) characterized by a lack of luminal continuity and blood flow from either the right ventricle or the pulmonary artery, together with… read more here.
Keywords: ventricular septal; atresia ventricular; t256m; pulmonary atresia ... See more keywords
Mantle cell lymphoma in 2022 - A comprehensive update on molecular pathogenesis, risk stratification, clinical approach, and current and novel treatments.
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DOI: 10.1002/ajh.26523
Abstract: The field of mantle cell lymphoma (MCL) has witnessed remarkable progress due to relentless advances in molecular pathogenesis, prognostication, and newer treatments. MCL consists of a spectrum of clinical subtypes. Rarely, atypical cyclin D1-negative MCL… read more here.
Keywords: cell lymphoma; mcl; molecular pathogenesis; mantle cell ... See more keywords
Cadherins and the pathogenesis of epilepsy
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DOI: 10.1002/cbf.3699
Abstract: Epilepsy is a nervous system disease caused by abnormal discharge of brain neurons, which is characterized by recurrent seizures. The factors that induce epilepsy include genetic and environmental factors. Genetic factors are important pathogenic factors… read more here.
Keywords: pathogenesis epilepsy; pathogenesis; brain; epilepsy ... See more keywords
Potential proteomic alteration in the brain of Tg(SOD1*G93A)1Gur mice: A new pathogenesis insight of amyotrophic lateral sclerosis
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DOI: 10.1002/cbin.11842
Abstract: The pathogenesis of amyotrophic lateral sclerosis (ALS) remains unclear. The recent studies have suggested that the protein abnormalities could play some important roles in ALS because several protein mutations were found in individuals with this… read more here.
Keywords: sod1 g93a; g93a 1gur; lateral sclerosis; pathogenesis ... See more keywords
Regional differences in gallbladder cancer pathogenesis: Insights from a multi‐institutional comparison of tumor mutations
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DOI: 10.1002/cncr.31850
Abstract: Although rare in the United States, gallbladder cancer (GBCA) is a common cause of cancer death in some parts of the world. To investigate regional differences in pathogenesis and outcomes for GBCA, tumor mutations were… read more here.
Keywords: regional differences; pathogenesis; tumor mutations; cancer ... See more keywords
Pathogenesis of E-Cigarette Vaping Product Use-Associated Lung Injury (EVALI).
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DOI: 10.1002/cphy.c220022
Abstract: EVALI is an acute inflammatory disease in response to lung cell injury induced by electronic cigarettes and vaping devices (EV) frequently containing Vitamin E Acetate or tetrahydrocannabinol additives, in the context of risk factors such… read more here.
Keywords: evali; pathogenesis cigarette; pathogenesis; injury ... See more keywords
The LncRNA AK018453 regulates TRAP1/Smad signaling in IL‐17‐activated astrocytes: A potential role in EAE pathogenesis
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DOI: 10.1002/glia.24239
Abstract: The pro‐inflammatory cytokine interleukin 17 (IL‐17), that is mainly produced by Th17 cells, has been recognized as a key regulator in multiple sclerosis (MS) and experimental autoimmune encephalomyelitis (EAE). Reactive astrocytes stimulated by proinflammatory cytokines… read more here.
Keywords: lncrna ak018453; role; trap1 smad; pathogenesis ... See more keywords
Evaluation on the effect of hydrogen sulfide on the NLRP3 signaling pathway and its involvement in the pathogenesis of atherosclerosis
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DOI: 10.1002/jcb.27404
Abstract: As a common disease, the incidence of atherosclerosis (AS) in the world is high. Therefore, we aimed to evaluate the involvement of hydrogen sulfide (H 2S)/cystathionine γ‐lyase (CSE) in the pathogenesis of AS as well… read more here.
Keywords: pathogenesis; effect hydrogen; evaluation effect; hydrogen sulfide ... See more keywords
Role of TGF‐β signaling regulatory microRNAs in the pathogenesis of colorectal cancer
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DOI: 10.1002/jcp.28169
Abstract: Transforming growth factor β (TGF‐β) modulates tumor progression by regulating cell proliferation, apoptosis, metastasis, angiogenesis, and drug resistance. Biological and pharmacological agonists/antagonists, the interplay between intracellular signaling pathways, and microRNAs (miRNAs) control the initiation and… read more here.
Keywords: role tgf; pathogenesis; tgf; signaling regulatory ... See more keywords
miRNA in Parkinson's disease: From pathogenesis to theranostic approaches
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DOI: 10.1002/jcp.30932
Abstract: Parkinson's disease (PD) is an age associated neurological disorder which is specified by cardinal motor symptoms such as tremor, stiffness, bradykinesia, postural instability, and non‐motor symptoms. Dopaminergic neurons degradation in substantia nigra region and aggregation… read more here.
Keywords: pathogenesis theranostic; disease pathogenesis; mirna parkinson; parkinson disease ... See more keywords
Potential roles of NLRP3 inflammasome in the pathogenesis of Kawasaki disease
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DOI: 10.1002/jcp.30948
Abstract: There is a heterogeneous group of rare illnesses that fall into the vasculitis category and are characterized mostly by blood vessel inflammation. Ischemia and disrupted blood flow will cause harm to the organs whose blood… read more here.
Keywords: kawasaki disease; etiology; pathogenesis; potential roles ... See more keywords