Molecular pathogenesis of acquired aplastic anemia
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DOI: 10.1111/ejh.13182
Abstract: The application of next‐generation sequencing (NGS) has enhanced our understanding of the genetic landscape in acquired aplastic anemia (AA). Parallel progress has been in addressing aspects underlying immune dysregulation in disease pathogenesis. Novel insights into… read more here.
Keywords: pathogenesis acquired; acquired aplastic; aplastic anemia; molecular pathogenesis ... See more keywords
Pathogenesis of Acquired Aplastic Anemia and the Role of the Bone Marrow Microenvironment
Sign Up to like & getrecommendations! Published in 2018 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2018.00587
Abstract: Aplastic anemia (AA) is characterized by bone marrow (BM) hypocellularity, resulting in peripheral cytopenias. An antigen-driven and likely auto-immune dysregulated T-cell homeostasis results in hematopoietic stem cell injury, which ultimately leads to the pathogenesis of… read more here.
Keywords: bone; pathogenesis acquired; aplastic anemia; bone marrow ... See more keywords