Microglial cGAS Deletion Preserves Intercellular Communication and Alleviates Amyloid‐β‐Induced Pathogenesis of Alzheimer's Disease
Sign Up to like & getrecommendations! Published in 2025 at "Advanced Science"
DOI: 10.1002/advs.202410910
Abstract: Innate immune activation plays a crucial role in the pathogenesis of Alzheimer's disease (AD) and related dementias (ADRD). The cytosolic DNA sensing pathway, involving cGAMP synthase (cGAS) and Stimulator of Interferon Genes (STING), has emerged… read more here.
Keywords: pathogenesis alzheimer; alzheimer disease; cgas; microglial cgas ... See more keywords
Effects of Acetylcholine on β-Amyloid-Induced cPLA2 Activation in the TB Neuroectodermal Cell Line: Implications for the Pathogenesis of Alzheimer’s Disease
Sign Up to like & getrecommendations! Published in 2017 at "Cellular and Molecular Neurobiology"
DOI: 10.1007/s10571-017-0555-4
Abstract: The role of β-amyloid (Aβ) in the pathogenesis of Alzheimer’s disease (AD) is still considered crucial. The state of Aβ aggregation is critical in promoting neuronal loss and neuronal function impairment. Recently, we demonstrated that… read more here.
Keywords: pathogenesis alzheimer; alzheimer disease; cell line; ach ... See more keywords
Ceramides may Play a Central Role in the Pathogenesis of Alzheimer’s Disease: a Review of Evidence and Horizons for Discovery
Sign Up to like & getrecommendations! Published in 2025 at "Molecular Neurobiology"
DOI: 10.1007/s12035-025-04989-0
Abstract: While several hypotheses have been proposed to explain the underlying mechanisms of Alzheimer's disease, none have been entirely satisfactory. Both genetic and non-genetic risk factors, such as infections, metabolic disorders and psychological stress, contribute to… read more here.
Keywords: pathogenesis alzheimer; alzheimer disease; disease; ceramides may ... See more keywords
Intrinsically disordered proteins in various hypotheses on the pathogenesis of Alzheimer's and Parkinson's diseases.
Sign Up to like & getrecommendations! Published in 2019 at "Progress in molecular biology and translational science"
DOI: 10.1016/bs.pmbts.2019.05.007
Abstract: Amyloid-β (Aβ) and α-synuclein (αS) are two intrinsically disordered proteins (IDPs) at the centers of the pathogenesis of Alzheimer's and Parkinson's diseases, respectively. Different hypotheses have been proposed for explanation of the molecular mechanisms of… read more here.
Keywords: intrinsically disordered; biology; parkinson diseases; disordered proteins ... See more keywords
The role of exosomes in the pathogenesis of Alzheimer’ disease
Sign Up to like & getrecommendations! Published in 2017 at "Translational Neurodegeneration"
DOI: 10.1186/s40035-017-0072-x
Abstract: Exosomes are small vesicles secreted by most cell types including neurons that function in intercellular communication through transfer of their cargo or encapsulate and eliminate unnecessary cellular components and therefore have a broad impact on… read more here.
Keywords: alzheimer disease; role exosomes; disease; exosomes pathogenesis ... See more keywords
Role of LRP1 in the pathogenesis of Alzheimer’s disease: evidence from clinical and preclinical studies
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Lipid Research"
DOI: 10.1194/jlr.r075796
Abstract: Among the LDL receptor (LDLR) family members, the roles of LDLR-related protein (LRP)1 in the pathogenesis of Alzheimer’s disease (AD), especially late-onset AD, have been the most studied by genetic, neuropathological, and biomarker analyses (clinical… read more here.
Keywords: preclinical studies; alzheimer disease; evidence; pathogenesis ... See more keywords
Inflammation in the CNS - understanding various aspects of the pathogenesis of Alzheimer's disease.
Sign Up to like & getrecommendations! Published in 2021 at "Current Alzheimer research"
DOI: 10.2174/1567205018666211202143935
Abstract: Alzheimer's disease is a progressive and deadly neurodegenerative disorder, and one of the most common causes of dementia in the world. Current, insufficiently sensitive and specific methods of early diagnosis and monitoring of this disease… read more here.
Keywords: inflammation cns; cns understanding; understanding various; disease ... See more keywords
Neuroinflammatory Signaling in the Pathogenesis of Alzheimer's Disease.
Sign Up to like & getrecommendations! Published in 2021 at "Current neuropharmacology"
DOI: 10.2174/1570159x19666210826130210
Abstract: Alzheimer's disease (AD) is a chronic neurodegenerative disease characterized by the formation of intracellular neurofibrillary tangles (NFTs) and extracellular amyloid plaques. Growing evidence has suggested that AD pathogenesis is not only limited to the neuronal… read more here.
Keywords: pathogenesis; signaling pathogenesis; pathogenesis alzheimer; alzheimer disease ... See more keywords
Most Pathways Can Be Related to the Pathogenesis of Alzheimer’s Disease
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Aging Neuroscience"
DOI: 10.3389/fnagi.2022.846902
Abstract: Alzheimer’s disease (AD) is a complex neurodegenerative disorder. The relative contribution of the numerous underlying functional mechanisms is poorly understood. To comprehensively understand the context and distribution of pathways that contribute to AD, we performed… read more here.
Keywords: pathogenesis alzheimer; related pathogenesis; disease; alzheimer disease ... See more keywords
Excessive/Aberrant and Maladaptive Synaptic Plasticity: A Hypothesis for the Pathogenesis of Alzheimer’s Disease
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Aging Neuroscience"
DOI: 10.3389/fnagi.2022.913693
Abstract: The amyloid hypothesis for the pathogenesis of Alzheimer’s disease (AD) is widely accepted. Last year, the US Food and Drug Administration considered amyloid-β peptide (Aβ) as a surrogate biomarker and approved an anti-Aβ antibody, aducanumab,… read more here.
Keywords: pathogenesis alzheimer; hypothesis; alzheimer disease; hypothesis pathogenesis ... See more keywords
Circulating extracellular vesicle-containing microRNAs reveal potential pathogenesis of Alzheimer’s disease
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Cellular Neuroscience"
DOI: 10.3389/fncel.2022.955511
Abstract: The pathogenesis of Alzheimer’s disease (AD) remains unknown till today, hindering the research and development of AD therapeutics and diagnostics. Circulating extracellular vesicles (EVs) can be utilized as a new window to spy upon AD… read more here.
Keywords: circulating extracellular; pathogenesis alzheimer; alzheimer disease; pathogenesis ... See more keywords