Effects of Acetylcholine on β-Amyloid-Induced cPLA2 Activation in the TB Neuroectodermal Cell Line: Implications for the Pathogenesis of Alzheimer’s Disease
Sign Up to like & getrecommendations! Published in 2017 at "Cellular and Molecular Neurobiology"
DOI: 10.1007/s10571-017-0555-4
Abstract: The role of β-amyloid (Aβ) in the pathogenesis of Alzheimer’s disease (AD) is still considered crucial. The state of Aβ aggregation is critical in promoting neuronal loss and neuronal function impairment. Recently, we demonstrated that… read more here.
Keywords: pathogenesis alzheimer; alzheimer disease; cell line; ach ... See more keywords
Intrinsically disordered proteins in various hypotheses on the pathogenesis of Alzheimer's and Parkinson's diseases.
Sign Up to like & getrecommendations! Published in 2019 at "Progress in molecular biology and translational science"
DOI: 10.1016/bs.pmbts.2019.05.007
Abstract: Amyloid-β (Aβ) and α-synuclein (αS) are two intrinsically disordered proteins (IDPs) at the centers of the pathogenesis of Alzheimer's and Parkinson's diseases, respectively. Different hypotheses have been proposed for explanation of the molecular mechanisms of… read more here.
Keywords: intrinsically disordered; biology; parkinson diseases; disordered proteins ... See more keywords
The role of exosomes in the pathogenesis of Alzheimer’ disease
Sign Up to like & getrecommendations! Published in 2017 at "Translational Neurodegeneration"
DOI: 10.1186/s40035-017-0072-x
Abstract: Exosomes are small vesicles secreted by most cell types including neurons that function in intercellular communication through transfer of their cargo or encapsulate and eliminate unnecessary cellular components and therefore have a broad impact on… read more here.
Keywords: alzheimer disease; role exosomes; disease; exosomes pathogenesis ... See more keywords
Role of LRP1 in the pathogenesis of Alzheimer’s disease: evidence from clinical and preclinical studies
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Lipid Research"
DOI: 10.1194/jlr.r075796
Abstract: Among the LDL receptor (LDLR) family members, the roles of LDLR-related protein (LRP)1 in the pathogenesis of Alzheimer’s disease (AD), especially late-onset AD, have been the most studied by genetic, neuropathological, and biomarker analyses (clinical… read more here.
Keywords: preclinical studies; alzheimer disease; evidence; pathogenesis ... See more keywords
Inflammation in the CNS - understanding various aspects of the pathogenesis of Alzheimer's disease.
Sign Up to like & getrecommendations! Published in 2021 at "Current Alzheimer research"
DOI: 10.2174/1567205018666211202143935
Abstract: Alzheimer's disease is a progressive and deadly neurodegenerative disorder, and one of the most common causes of dementia in the world. Current, insufficiently sensitive and specific methods of early diagnosis and monitoring of this disease… read more here.
Keywords: inflammation cns; cns understanding; understanding various; disease ... See more keywords
Neuroinflammatory Signaling in the Pathogenesis of Alzheimer's Disease.
Sign Up to like & getrecommendations! Published in 2021 at "Current neuropharmacology"
DOI: 10.2174/1570159x19666210826130210
Abstract: Alzheimer's disease (AD) is a chronic neurodegenerative disease characterized by the formation of intracellular neurofibrillary tangles (NFTs) and extracellular amyloid plaques. Growing evidence has suggested that AD pathogenesis is not only limited to the neuronal… read more here.
Keywords: pathogenesis; signaling pathogenesis; pathogenesis alzheimer; alzheimer disease ... See more keywords
Most Pathways Can Be Related to the Pathogenesis of Alzheimer’s Disease
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Aging Neuroscience"
DOI: 10.3389/fnagi.2022.846902
Abstract: Alzheimer’s disease (AD) is a complex neurodegenerative disorder. The relative contribution of the numerous underlying functional mechanisms is poorly understood. To comprehensively understand the context and distribution of pathways that contribute to AD, we performed… read more here.
Keywords: pathogenesis alzheimer; related pathogenesis; disease; alzheimer disease ... See more keywords
Excessive/Aberrant and Maladaptive Synaptic Plasticity: A Hypothesis for the Pathogenesis of Alzheimer’s Disease
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Aging Neuroscience"
DOI: 10.3389/fnagi.2022.913693
Abstract: The amyloid hypothesis for the pathogenesis of Alzheimer’s disease (AD) is widely accepted. Last year, the US Food and Drug Administration considered amyloid-β peptide (Aβ) as a surrogate biomarker and approved an anti-Aβ antibody, aducanumab,… read more here.
Keywords: pathogenesis alzheimer; hypothesis; alzheimer disease; hypothesis pathogenesis ... See more keywords
Circulating extracellular vesicle-containing microRNAs reveal potential pathogenesis of Alzheimer’s disease
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Cellular Neuroscience"
DOI: 10.3389/fncel.2022.955511
Abstract: The pathogenesis of Alzheimer’s disease (AD) remains unknown till today, hindering the research and development of AD therapeutics and diagnostics. Circulating extracellular vesicles (EVs) can be utilized as a new window to spy upon AD… read more here.
Keywords: circulating extracellular; pathogenesis alzheimer; alzheimer disease; pathogenesis ... See more keywords
Antimicrobial Peptides (AMPs) in the Pathogenesis of Alzheimer’s Disease: Implications for Diagnosis and Treatment
Sign Up to like & getrecommendations! Published in 2022 at "Antibiotics"
DOI: 10.3390/antibiotics11060726
Abstract: Alzheimer’s disease (AD) represents the most frequent type of dementia in elderly people. There are two major forms of the disease: sporadic (SAD)—whose causes are not completely understood—and familial (FAD)—with clear autosomal dominant inheritance. The… read more here.
Keywords: pathogenesis alzheimer; alzheimer disease; amps pathogenesis; antimicrobial peptides ... See more keywords
Roles of ZnT86D in Neurodevelopment and Pathogenesis of Alzheimer Disease in a Drosophila melanogaster Model
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms231911832
Abstract: Zinc is a fundamental trace element essential for numerous biological processes, and zinc homeostasis is regulated by the Zrt-/Irt-like protein (ZIP) and zinc transporter (ZnT) families. ZnT7 is mainly localized in the Golgi apparatus and… read more here.
Keywords: pathogenesis alzheimer; zinc; alzheimer disease; drosophila ... See more keywords