Hippocampal FXR plays a role in the pathogenesis of depression: A preliminary study based on lentiviral gene modulation
Sign Up to like & getrecommendations! Published in 2018 at "Psychiatry Research"
DOI: 10.1016/j.psychres.2018.04.025
Abstract: As a well-known bile acid receptor, the role of Farnesoid X receptor (FXR) in the digestive system and cardiovascular system has been widely explored. However, there are very few studies involving FXR in the central nervous… read more here.
Keywords: fxr; hippocampal fxr; system; pathogenesis depression ... See more keywords
Hippocampal miR-124 participates in the pathogenesis of depression via regulating the expression of BDNF in a Chronic Social Defeat Stress model of depression.
Sign Up to like & getrecommendations! Published in 2022 at "Current neurovascular research"
DOI: 10.2174/1567202619666220713105306
Abstract: Objective As one of the most prevalent psychiatric disorders, the exact pathogenesis of depression remains elusive. Therefore, there is an urgent need to identify novel antidepressants for effective treatment. MicroRNA-124 (miR-124), the most abundant miRNA… read more here.
Keywords: pathogenesis depression; mir 124; depression; model depression ... See more keywords
Neurotrophic basis to the pathogenesis of depression and phytotherapy
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2023.1182666
Abstract: Depression is a major neuropsychiatric disease that considerably impacts individuals’ psychosocial function and life quality. Neurotrophic factors are now connected to the pathogenesis of depression, while the definitive neurotrophic basis remains elusive. Besides, phytotherapy is… read more here.
Keywords: neurotrophic factors; depression; pathogenesis depression; neurotrophic basis ... See more keywords