Kynureninase contributes to the pathogenesis of psoriasis through pro-inflammatory effect.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of cellular physiology"
DOI: 10.1002/jcp.30587
Abstract: Kynureninase (KYNU) is a key enzyme in the tryptophan metabolism pathway with elevated expression in psoriatic lesions relative to normal skin. However, whether KYNU contributes to the pathogenesis of psoriasis remains unknown. We sought to… read more here.
Keywords: kynureninase; kynu; skin; psoriasis ... See more keywords
The importance of ADAM10 and ADAM17 metalloproteinases in the pathogenesis of psoriasis.
Sign Up to like & getrecommendations! Published in 2022 at "Clinical and experimental dermatology"
DOI: 10.1111/ced.15239
Abstract: BACKGROUND Psoriasis is a chronic inflammatory skin disorder characterized by inflammation, hyperproliferation, andneoangiogenesis. The disease pathogenesis has not been fully elucidated. ADAM17 and ADAM10 are important proteases serving as regulators of inflammation. OBJECTIVES This study… read more here.
Keywords: adam17; psoriasis; adam10 adam17; pathogenesis psoriasis ... See more keywords
The study of GSDMB in pathogenesis of psoriasis vulgaris
Sign Up to like & getrecommendations! Published in 2023 at "PLOS ONE"
DOI: 10.1371/journal.pone.0279908
Abstract: Background Gasdermin (GSDM) B is a member of the GSDM family, which is a protein that may be involved in the cell pyroptosis process and is associated with inflammatory diseases. Objective To explore the correlation… read more here.
Keywords: psoriasis vulgaris; cell; gsdmb; pathogenesis psoriasis ... See more keywords
The role of intradermal proliferation of T-cells in the pathogenesis of psoriasis*
Sign Up to like & getrecommendations! Published in 2017 at "Anais Brasileiros de Dermatologia"
DOI: 10.1590/abd1806-4841.20175765
Abstract: BACKGROUND Psoriasis is a common immune-mediated chronic inflammatory disease of the skin and joints, affecting 1-3% of the population. It is generally accepted that the pathogenesis of psoriasis involves accumulation of effector T-cells within lymph… read more here.
Keywords: psoriasis; intradermal proliferation; pathogenesis psoriasis; proliferation cells ... See more keywords
Role of Fetuin-A in the Pathogenesis of Psoriasis and Its Potential Clinical Applications
Sign Up to like & getrecommendations! Published in 2022 at "Clinical, Cosmetic and Investigational Dermatology"
DOI: 10.2147/ccid.s356801
Abstract: Abstract Fetuin-A is a plasma glycoprotein exhibiting multifaceted physiological and pathological functions. It has been determined to be involved in various essential biological functions, such as regulation of calcium metabolism, osteogenesis, and insulin signaling pathway.… read more here.
Keywords: role; role fetuin; fetuin pathogenesis; pathogenesis psoriasis ... See more keywords
Discovering Novel Biomarkers Associated with the Pathogenesis of Psoriasis: Evidence from Bioinformatic Analysis
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of General Medicine"
DOI: 10.2147/ijgm.s354985
Abstract: Objective This study aimed to investigate key biomarkers and their molecular pathogenesis in psoriasis. Methods Differentially expressed genes (DEGs) of datasets (GSE13355, GSE30999, and GSE106992) obtained from Gene Expression Omnibus (GEO) were identified using Venn… read more here.
Keywords: analysis showed; pathogenesis psoriasis; psoriasis; cxcl8 ... See more keywords
Effects of Neuropeptides on Dendritic Cells in the Pathogenesis of Psoriasis
Sign Up to like & getrecommendations! Published in 2023 at "Journal of Inflammation Research"
DOI: 10.2147/jir.s397079
Abstract: Abstract Psoriasis is an autoimmune disease that is characterized by discolored, scaled patches of skin. Clinically, it is found that psychological factors often induce or aggravate the disease. Current research suggests that the pathogenesis of… read more here.
Keywords: effects neuropeptides; dendritic cells; pathogenesis psoriasis; cells pathogenesis ... See more keywords
Del-1 in psoriasis induced the expression of αvβ3 and α5β1 in endothelial cells.
Sign Up to like & getrecommendations! Published in 2021 at "Current molecular medicine"
DOI: 10.2174/1566524021666210729112700
Abstract: OBJECTIVE Psoriasis is a chronic inflammatory skin disease highly depending on angiogenesis. Our prior results showed that the mRNA and protein of Del-1 in dermal mesenchymal stem cells (dMSCs) was up-regulated from psoriasis. Our aim… read more here.
Keywords: del; expression; psoriasis induced; psoriasis ... See more keywords
C5a/C5aR1 Pathway Is Critical for the Pathogenesis of Psoriasis
Sign Up to like & getrecommendations! Published in 2019 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2019.01866
Abstract: Psoriasis is one of the most common chronic inflammatory skin diseases, affecting ~2% of the population. The lack of characterization of the pathogenesis of psoriasis has hindered efficient clinical treatment of the disease. In our… read more here.
Keywords: psoriasis; pathogenesis psoriasis; c5a c5ar1; c5ar1 ... See more keywords
Dendritic Cells and Macrophages in the Pathogenesis of Psoriasis
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.941071
Abstract: Psoriasis is a chronic inflammatory skin disease characterized by scaly indurated erythema. This disease impairs patients’ quality of life enormously. Pathological findings demonstrate proliferation and abnormal differentiation of keratinocytes and massive infiltration of inflammatory immune… read more here.
Keywords: macrophages pathogenesis; dendritic cells; pathogenesis psoriasis; psoriasis ... See more keywords
Inducible nitric oxide synthase-expressing myeloid-derived suppressor cells regulated by interleukin 35 contribute to the pathogenesis of psoriasis
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2023.1091541
Abstract: Although psoriasis is classified as a T cell-mediated inflammatory disease, the contribution of myeloid cells to the pathogenesis of psoriasis is not fully understood. In the present study, we demonstrated that the expression of the… read more here.
Keywords: inducible nitric; nitric oxide; oxide synthase; pathogenesis psoriasis ... See more keywords