IL-6/gp130 signaling in CD4+ T cells drives the pathogenesis of pulmonary hypertension
Sign Up to like & getrecommendations! Published in 2024 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2315123121
Abstract: Significance IL-6 signaling has a pivotal role in the pathogenesis of pulmonary arterial hypertension (PAH). However, the target cells of IL-6 signaling in PAH have been elusive. Here, we revealed that SM22α-Cre mice show unexpected… read more here.
Keywords: pah; cd4 cells; gp130 signaling; pathogenesis pulmonary ... See more keywords
New Mutations and Pathogenesis of Pulmonary Hypertension: Progress and Puzzles in Disease Pathogenesis
Sign Up to like & getrecommendations! Published in 2022 at "Circulation Research"
DOI: 10.1161/circresaha.122.320084
Abstract: Pulmonary arterial hypertension (PAH) is a complex multifactorial disease with poor prognosis characterized by functional and structural alterations of the pulmonary circulation causing marked increase in pulmonary vascular resistance, ultimately leading to right heart failure… read more here.
Keywords: pathogenesis pulmonary; pulmonary hypertension; hypertension; mutations pathogenesis ... See more keywords
Insights into the Pathogenesis of Pulmonary Fibrosis from Genetic Diseases.
Sign Up to like & getrecommendations! Published in 2022 at "American journal of respiratory cell and molecular biology"
DOI: 10.1165/rcmb.2021-0557tr
Abstract: Pulmonary fibrosis is a disease process associated with significant morbidity and mortality, with limited therapeutic options due to an incomplete understanding of the underlying pathophysiology. Mechanisms driving the fibrotic cascade have been elucidated through studies… read more here.
Keywords: pathogenesis pulmonary; genetic diseases; fibrosis genetic; pulmonary fibrosis ... See more keywords