The gut microbiota promotes the pathogenesis of schizophrenia via multiple pathways.
Sign Up to like & getrecommendations! Published in 2019 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2019.02.152
Abstract: Schizophrenia is a severe mental disorder with unknown etiology. Many mechanisms, including dysregulation of neurotransmitters, immune disturbance, and abnormal neurodevelopment, are proposed for the pathogenesis of schizophrenia. The significance of communication between intestinal flora and… read more here.
Keywords: schizophrenia; promotes pathogenesis; intestinal flora; pathogenesis schizophrenia ... See more keywords
Histamine H2 receptor deficit in glutamatergic neurons contributes to the pathogenesis of schizophrenia.
Sign Up to like & getrecommendations! Published in 2023 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2207003120
Abstract: Schizophrenia is a serious mental disorder, and existing antipsychotic drugs show limited efficacy and cause unwanted side effects. The development of glutamatergic drugs for schizophrenia is currently challenging. Most functions of histamine in the brain… read more here.
Keywords: h2r; glutamatergic neurons; pathogenesis schizophrenia; receptor ... See more keywords