Epigenetics and pathogenesis of systemic sclerosis; the ins and outs.
Sign Up to like & getrecommendations! Published in 2018 at "Human immunology"
DOI: 10.1016/j.humimm.2018.01.003
Abstract: The pathogenesis of many diseases is influenced by environmental factors which can affect human genome and be inherited from generation to generation. Adverse environmental stimuli are recognized through the epigenetic regulatory complex, leading to gene… read more here.
Keywords: sclerosis ins; pathogenesis systemic; ins outs; systemic sclerosis ... See more keywords
Is there a role for IL-17 in the pathogenesis of systemic sclerosis?
Sign Up to like & getrecommendations! Published in 2018 at "Immunology letters"
DOI: 10.1016/j.imlet.2017.09.007
Abstract: In systemic sclerosis (SSc) immuno-inflammatory events are central to disease development. Amongst other mediators of inflammation, interleukin 17 (IL-17) and Th17 cells have been reported to be increased in the peripheral blood and target organs… read more here.
Keywords: sclerosis; ssc; pathogenesis systemic; production ... See more keywords
The role of B cells in the pathogenesis of systemic sclerosis: an update.
Sign Up to like & getrecommendations! Published in 2022 at "Rheumatology"
DOI: 10.1093/rheumatology/keac578
Abstract: The pathogenesis of systemic sclerosis (SSc) is incompletely understood but several lines of evidence suggest that B cells are involved. Effector B (Beff) cells are hyperactivated and produce autoantibodies (autoAbs) and regulatory B cells (Bregs)… read more here.
Keywords: systemic sclerosis; cells pathogenesis; role cells; fibrosis ... See more keywords