COMPARATIVE TRANSCRIPTOMIC ANALYSIS IDENTIFIES EPITHELIAL-MESENCHYMAL TRANSITION AND INFLAMMATION AS COMMON PATHOGENETIC MECHANISMS IN HYPERTENSIVE AND DIABETIC NEPHROPATHY
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DOI: 10.1097/01.hjh.0000835660.98967.bc
Abstract: Objective: Type 2 diabetic (T2DN) and hypertensive nephrosclerosis (HN) are the main causes of chronic kidney disease (CKD). To obtain novel insights into pathogenetic mechanisms, potentially suggesting common therapeutic procedures, we comparatively nalysed transcriptomes of… read more here.
Keywords: common pathogenetic; mesenchymal transition; pathogenetic mechanisms; kidney ... See more keywords
Hypertensive nephropathy. Moving from classic to emerging pathogenetic mechanisms
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DOI: 10.1097/hjh.0000000000001170
Abstract: Hypertensive kidney disease classically entails nephroangiosclerosis and hyalinosis with glomerular damage. However, in recent years, several evidences showed that high blood pressure also injures tubular cells, inducing epithelial-to-mesenchymal transition and tubulointerstitial fibrosis. Recently investigated mechanisms… read more here.
Keywords: emerging pathogenetic; hypertensive nephropathy; moving classic; nephropathy moving ... See more keywords
Pathogenetic mechanisms and signs of cardiovascular disorders in type 2 diabetes mellitus
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DOI: 10.22141/2224-0721.14.3.2018.136418
Abstract: Background . A high morbidity and prevalence of diabetes mellitus (DM) cause early disability and mortality due to the development of chronic complications. The main cause of death in type 2 DM is associated with… read more here.
Keywords: disorders type; mechanisms signs; signs cardiovascular; diabetes mellitus ... See more keywords
Pathogenetic Mechanisms of Hypertension–Brain-Induced Complications: Focus on Molecular Mediators
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DOI: 10.3390/ijms23052445
Abstract: There is growing evidence that hypertension is the most important vascular risk factor for the development and progression of cardiovascular and cerebrovascular diseases. The brain is an early target of hypertension-induced organ damage and may… read more here.
Keywords: pathogenetic mechanisms; hypertension; hypertension brain; brain ... See more keywords
Peripheral Neuropathy in Diabetes Mellitus: Pathogenetic Mechanisms and Diagnostic Options
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DOI: 10.3390/ijms24043554
Abstract: Diabetic neuropathy (DN) is one of the main microvascular complications of both type 1 and type 2 diabetes mellitus. Sometimes, this could already be present at the time of diagnosis for type 2 diabetes mellitus… read more here.
Keywords: mellitus pathogenetic; pathogenetic mechanisms; peripheral neuropathy; neuropathy diabetes ... See more keywords
Can SARS-CoV-2 Infection Exacerbate Alzheimer’s Disease? An Overview of Shared Risk Factors and Pathogenetic Mechanisms
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DOI: 10.3390/jpm12010029
Abstract: The current coronavirus disease 2019 (COVID-19) pandemic, caused by severe acute respiratory syndrome coronavirus (SARS-CoV)-2, is affecting every aspect of global society, including public healthcare systems, medical care access, and the economy. Although the respiratory… read more here.
Keywords: pathogenetic mechanisms; disease; alzheimer disease; risk factors ... See more keywords