Interplay of pathogenic forms of human tau with different autophagic pathways
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DOI: 10.1111/acel.12692
Abstract: Loss of neuronal proteostasis, a common feature of the aging brain, is accelerated in neurodegenerative disorders, including different types of tauopathies. Aberrant turnover of tau, a microtubule‐stabilizing protein, contributes to its accumulation and subsequent toxicity… read more here.
Keywords: degradation; degradation tau; tau; pathogenic forms ... See more keywords
Rational Generation of Monoclonal Antibodies Selective for Pathogenic Forms of Alpha-Synuclein
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DOI: 10.3390/biomedicines10092168
Abstract: Misfolded toxic forms of alpha-synuclein (α-Syn) have been implicated in the pathogenesis of synucleinopathies, including Parkinson’s disease (PD), dementia with Lewy bodies (DLB), and multiple system atrophy (MSA). The α-Syn oligomers and soluble fibrils have… read more here.
Keywords: pathogenic forms; forms alpha; selective pathogenic; alpha synuclein ... See more keywords