Pathogenic Aβ generation in familial Alzheimer’s disease: novel mechanistic insights and therapeutic implications
Sign Up to like & getrecommendations! Published in 2020 at "Current Opinion in Neurobiology"
DOI: 10.1016/j.conb.2020.01.011
Abstract: Neurotoxic amyloid-β peptide (Aβ) 42/43 species generated by β-secretase and γ-secretase from the β-amyloid precursor protein (APP) are believed to trigger Alzheimer's disease (AD). Relative increases of these species due to mutations in APP and… read more here.
Keywords: alzheimer disease; familial alzheimer; generation familial; pathogenic generation ... See more keywords