Pathogenic implications of distinct patterns of iron and zinc in chronic MS lesions
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DOI: 10.1007/s00401-017-1696-8
Abstract: Multiple sclerosis (MS) is a chronic inflammatory demyelinating disease of the central nervous system (CNS) in which oligodendrocytes, the CNS cells that stain most robustly for iron and myelin are the targets of injury. Metals… read more here.
Keywords: chronic lesions; pathogenic implications; implications distinct; zinc ... See more keywords
Pathogenic implications for autoimmune mechanisms derived by comparative eQTL analysis of CD4+ versus CD8+ T cells
Sign Up to like & getrecommendations! Published in 2017 at "PLoS Genetics"
DOI: 10.1371/journal.pgen.1006643
Abstract: Inappropriate activation or inadequate regulation of CD4+ and CD8+ T cells may contribute to the initiation and progression of multiple autoimmune and inflammatory diseases. Studies on disease-associated genetic polymorphisms have highlighted the importance of biological… read more here.
Keywords: implications autoimmune; pathogenic implications; cd8 cells; autoimmune mechanisms ... See more keywords