Isolation of a novel DNA aptamer against LipL32 as a potential diagnostic agent for the detection of pathogenic Leptospira
Sign Up to like & getrecommendations! Published in 2022 at "Biotechnology Journal"
DOI: 10.1002/biot.202200418
Abstract: Leptospirosis is a potentially life‐threatening zoonosis caused by pathogenic Leptospira and for rapid diagnostics, direct detection is desirable. LipL32 protein is the most suitable biomarker for direct detection. DNA aptamers are sought to be generated… read more here.
Keywords: dna aptamer; pathogenic leptospira; detection; aptamer ... See more keywords
Development and validation of a modified TaqMan based real-time PCR assay targeting the lipl32 gene for detection of pathogenic Leptospira in canine urine samples
Sign Up to like & getrecommendations! Published in 2018 at "Brazilian Journal of Microbiology"
DOI: 10.1016/j.bjm.2017.09.004
Abstract: A modified TaqMan real-time polymerase chain reaction targeting a 138 bp fragment within the lipl32 gene was developed to identify exclusively pathogenic Leptospira spp. in dog urine samples. Thirty-five samples from dogs with suspected clinical… read more here.
Keywords: modified taqman; real time; pathogenic leptospira; gene ... See more keywords
Inactivation of the antimicrobial peptide LL-37 by pathogenic Leptospira.
Sign Up to like & getrecommendations! Published in 2020 at "Microbial pathogenesis"
DOI: 10.1016/j.micpath.2020.104704
Abstract: Leptospires are aerobic, Gram-negative spirochetes with a high invasive capacity. Pathogenic leptospires secrete proteases that inactivate a variety of host's proteins including molecules of the extracellular matrix and of the human complement system. This strategy,… read more here.
Keywords: peptide; leptospira; inactivation antimicrobial; antimicrobial peptide ... See more keywords
Pathogenic Leptospira and their animal reservoirs: testing host specificity through experimental infection
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DOI: 10.1038/s41598-020-64172-4
Abstract: Leptospirosis is caused by pathogenic Leptospira transmitted through contact with contaminated environments. Most mammalian species are infectable by Leptospira but only few act as efficient reservoir being capable of establishing long term kidney colonization and… read more here.
Keywords: experimental infection; leptospira; host; pathogenic leptospira ... See more keywords
Detection of pathogenic Leptospira species associated with phyllostomid bats (Mammalia: Chiroptera) from Veracruz, Mexico
Sign Up to like & getrecommendations! Published in 2018 at "Transboundary and Emerging Diseases"
DOI: 10.1111/tbed.12802
Abstract: The genus Leptospira encompass 22 species of spirochaetes, with ten pathogenic species that have been recorded in more than 160 mammals worldwide. In the last two decades, the numbers of records of these agents associated… read more here.
Keywords: veracruz mexico; detection pathogenic; leptospira; pathogenic leptospira ... See more keywords
Detection of pathogenic Leptospira spp. in herpetofauna in Central Appalachia
Sign Up to like & getrecommendations! Published in 2022 at "Zoonoses and Public Health"
DOI: 10.1111/zph.12921
Abstract: Leptospirosis is a water borne zoonotic disease of global significance that is caused by pathogenic species of the genus Leptospira. Pathogenic leptospires live in the kidneys of reservoir or infected animals and are shed in… read more here.
Keywords: central appalachia; seven species; leptospira; leptospira spp ... See more keywords
Diverse lineages of pathogenic Leptospira species are widespread in the environment in Puerto Rico, USA
Sign Up to like & getrecommendations! Published in 2022 at "PLoS Neglected Tropical Diseases"
DOI: 10.1371/journal.pntd.0009959
Abstract: Background Leptospirosis, caused by Leptospira bacteria, is a common zoonosis worldwide, especially in the tropics. Reservoir species and risk factors have been identified but surveys for environmental sources are rare. Furthermore, understanding of environmental Leptospira… read more here.
Keywords: leptospira species; environment puerto; puerto rico; leptospira ... See more keywords
Urinary shedding of pathogenic Leptospira in stray dogs and cats, Algiers: A prospective study
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DOI: 10.1371/journal.pone.0197068
Abstract: Background Leptospirosis is an important worldwide zoonosis. This disease is caused by pathogenic species of the genus Leptospira which are maintained in the environment via chronic renal infection of carrier animals which can be asymptomatic… read more here.
Keywords: stray dogs; leptospirosis; dogs cats; leptospira ... See more keywords
Cats shedding pathogenic Leptospira spp.—An underestimated zoonotic risk?
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DOI: 10.1371/journal.pone.0239991
Abstract: Shedding of DNA of pathogenic Leptospira spp. has been documented in naturally infected cats in several countries, but urinary shedding of infectious Leptospira spp. has only recently been proven. The climate in Southern Chile is… read more here.
Keywords: leptospira spp; shedding pathogenic; leptospira; pathogenic leptospira ... See more keywords
Development of lipL32 real-time PCR combined with an internal and extraction control for pathogenic Leptospira detection
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DOI: 10.1371/journal.pone.0241584
Abstract: At least two real-time PCRs for the early diagnosis of leptospirosis have been described, evaluated and validated. However, at least one other report suggested adaptation and modification of primers and probes used in these assays… read more here.
Keywords: detection; real time; control; leptospira ... See more keywords
A Systematic Review of the geographic distribution of pathogenic Leptospira serovars in the Americas, 1930-2017.
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DOI: 10.1590/0001-3765202220201026
Abstract: Leptospirosis is an important public health problem caused by Leptospira. The objective is to characterize the geographic distribution of pathogenic leptospira serovars in the Americas through a systematic review of the literature between 1930-2017. Searches… read more here.
Keywords: distribution pathogenic; serovars americas; leptospira serovars; leptospira ... See more keywords