SARS-CoV-2: Pathogenic Mechanisms and Host Immune Response.
Sign Up to like & getrecommendations! Published in 2021 at "Advances in experimental medicine and biology"
DOI: 10.1007/978-3-030-67452-6_6
Abstract: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is an enveloped, positive-sense RNA coronavirus responsible for the COVID-19 pandemic. Since December 2019, coronavirus disease 2019 (COVID-19) has affected more than 127 million people, 2.7 million deaths… read more here.
Keywords: response; cov pathogenic; pathogenic mechanisms; immune response ... See more keywords
Role of Oxidative Stress in Lithium-Induced Nephropathy
Sign Up to like & getrecommendations! Published in 2019 at "Biological Trace Element Research"
DOI: 10.1007/s12011-018-1617-2
Abstract: Long-term lithium treatment was associated with chronic kidney disease and renal failure although the underlying pathogenic mechanisms are not certainty known. The aim of this study was to evaluate changes in oxidative stress measures as… read more here.
Keywords: pathogenic mechanisms; lithium; induced nephropathy; lithium induced ... See more keywords
Biomarkers and Pathogenic Mechanisms in Autoimmunity
Sign Up to like & getrecommendations! Published in 2017 at "Immunologic Research"
DOI: 10.1007/s12026-016-8864-0
Abstract: The overall frequency of all autoimmune diseases in the general population is estimated at 5–8 %. More importantly, there has been an alarming increase in incidence for autoimmune diseases in recent decades. All ages are… read more here.
Keywords: autoimmune; mechanisms autoimmunity; autoimmune diseases; pathogenic mechanisms ... See more keywords
Pathogenic Mechanisms of Cryptosporidium and Giardia.
Sign Up to like & getrecommendations! Published in 2017 at "Trends in parasitology"
DOI: 10.1016/j.pt.2017.02.006
Abstract: Intestinal protozoa are important etiological agents of diarrhea, particularly in children, yet the public health risk they pose is often neglected. Results from the Global Enteric Multicenter Study (GEMS) showed that Cryptosporidium is among the… read more here.
Keywords: mechanisms cryptosporidium; pathogenic mechanisms; cryptosporidium; cryptosporidium giardia ... See more keywords
Multi-omics profiling reveals distinct pathogenic mechanisms in Hunner and non-Hunner interstitial cystitis subtypes
Sign Up to like & getrecommendations! Published in 2025 at "Scientific Reports"
DOI: 10.1038/s41598-025-12010-w
Abstract: Bladder Pain Syndrome/Interstitial Cystitis encompasses Hunner lesion and non-Hunner lesion (NHIC) subtypes, characterized by chronic pelvic pain and urinary symptoms. The two subtypes show distinct clinical presentations, yet their underlying mechanisms remain poorly understood. Advancements… read more here.
Keywords: pathogenic mechanisms; interstitial cystitis; multi omics; hunner ... See more keywords
Neurological manifestations and pathogenic mechanisms of COVID-19
Sign Up to like & getrecommendations! Published in 2022 at "Neurological Research"
DOI: 10.1080/01616412.2021.2024732
Abstract: ABSTRACT Coronavirus disease (COVID-19) arising from severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) viral infection has caused a worldwide pandemic, mainly owing to its highly virulent nature stemming from a very strong and highly efficacious… read more here.
Keywords: mechanisms covid; manifestations pathogenic; neurological manifestations; pathogenic mechanisms ... See more keywords
Identification of viral-mediated pathogenic mechanisms in neurodegenerative diseases using network-based approaches.
Sign Up to like & getrecommendations! Published in 2021 at "Briefings in bioinformatics"
DOI: 10.1093/bib/bbab141
Abstract: During the course of a viral infection, virus-host protein-protein interactions (PPIs) play a critical role in allowing viruses to replicate and survive within the host. These interspecies molecular interactions can lead to viral-mediated perturbations of… read more here.
Keywords: network based; network; pathogenic mechanisms; mediated pathogenic ... See more keywords
Localization and functional characterization of the p.Asn965Ser (N965S) ABCA4 variant in mice reveal pathogenic mechanisms underlying Stargardt macular degeneration
Sign Up to like & getrecommendations! Published in 2018 at "Human Molecular Genetics"
DOI: 10.1093/hmg/ddx400
Abstract: ABCA4 is a member of the superfamily of ATP-binding cassette (ABC) proteins that transports N-retinylidene-phosphatidylethanolamine (N-Ret-PE) across outer segment disc membranes thereby facilitating the removal of potentially toxic retinoid compounds from photoreceptor cells. Mutations in… read more here.
Keywords: asn965ser n965s; abca4 variant; localization functional; pathogenic mechanisms ... See more keywords
Role of HIF‐1α in pathogenic mechanisms of keloids
Sign Up to like & getrecommendations! Published in 2023 at "Journal of Cosmetic Dermatology"
DOI: 10.1111/jocd.15601
Abstract: Keloids are defined as overrepairing products that develop after skin lesions. Keloids are characterized by the proliferation of fibroblasts and the overaccumulation of extracellular matrix components (mainly collagen), leading to a locally hypoxic microenvironment. Hence,… read more here.
Keywords: hif pathogenic; dermatology; mechanisms keloids; role hif ... See more keywords
Pathogenic mechanisms of cardiovascular damage in COVID-19
Sign Up to like & getrecommendations! Published in 2024 at "Molecular Medicine"
DOI: 10.1186/s10020-024-00855-2
Abstract: COVID-19 is a new infectious disease caused by the severe acute respiratory syndrome coronavirus 2 (SARS CoV-2). Since the outbreak in December 2019, it has caused an unprecedented world pandemic, leading to a global human… read more here.
Keywords: pathogenic mechanisms; mechanisms cardiovascular; damage; cardiovascular damage ... See more keywords
RNA-binding proteins in ALS and FTD: from pathogenic mechanisms to therapeutic insights
Sign Up to like & getrecommendations! Published in 2025 at "Molecular Neurodegeneration"
DOI: 10.1186/s13024-025-00851-y
Abstract: Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) are devastating neurodegenerative disorders with overlapping clinical, genetic and pathological features. A large body of evidence highlights the critical role of RNA-binding proteins (RBPs) – in particular… read more here.
Keywords: pathogenic mechanisms; ftd pathogenic; binding proteins; als ftd ... See more keywords