Biosynthesis of Isonitrile Lipopeptide Metallophores from Pathogenic Mycobacteria.
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DOI: 10.1021/acs.biochem.2c00611
Abstract: Isonitrile lipopeptides (INLPs) are known to be related to the virulence of pathogenic mycobacteria by mediating metal transport, but their biosynthesis remains obscure. In this work, we use in vitro biochemical assays, site-directed mutagenesis, chemical… read more here.
Keywords: biosynthesis; lipopeptide metallophores; isonitrile lipopeptide; metallophores pathogenic ... See more keywords
Direct Attachment with Erythrocytes Augments Extracellular Growth of Pathogenic Mycobacteria
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DOI: 10.1128/spectrum.02454-21
Abstract: Pathogenic mycobacteria, such as Mycobacterium tuberculosis, Mycobacterium avium subsp. hominissuis (MAH), and Mycobacterium intracellulare, cause pulmonary infections as intracellular parasites of lung macrophages and epithelial cells. Here, using histopathological examinations we found that MAH and… read more here.
Keywords: growth; tuberculosis; mycobacterium; mycobacterium avium ... See more keywords
IFN-γ fails to overcome inhibition of selected macrophage activation events in response to pathogenic mycobacteria
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DOI: 10.1371/journal.pone.0176400
Abstract: According to most models of mycobacterial infection, inhibition of the pro-inflammatory macrophage immune responses contributes to the persistence of bacteria. Mycobacterium avium subsp. paratuberculosis (MAP) is a highly successful pathogen in cattle and sheep and… read more here.
Keywords: pathogenic mycobacteria; response; ifn; inhibition ... See more keywords
Getting in and Staying Alive: Role for Coronin 1 in the Survival of Pathogenic Mycobacteria and Naïve T Cells
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DOI: 10.3389/fimmu.2018.01592
Abstract: There are many different pathogenic stimuli that are able to activate the immune system, ranging from microbes that include bacteria, viruses, fungi, and parasites to host-derived triggers such as autoantigens that can induce autoimmunity as… read more here.
Keywords: coronin; pathogenic mycobacteria; role coronin; survival pathogenic ... See more keywords
Saprophytic to Pathogenic Mycobacteria: Loss of Cytochrome P450s Vis a Vis Their Prominent Involvement in Natural Metabolite Biosynthesis
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DOI: 10.3390/ijms24010149
Abstract: Cytochrome P450 monooxygenases (P450s/CYPs) are ubiquitous enzymes with unique regio- and stereo-selective oxidation activities. Due to these properties, P450s play a key role in the biosynthesis of natural metabolites. Mycobacterial species are well-known producers of… read more here.
Keywords: biosynthesis; natural metabolite; vis vis; p450s ... See more keywords