Pathogenic Pathways in Early-Onset Autosomal Recessive Parkinson's Disease Discovered Using Isogenic Human Dopaminergic Neurons
Sign Up to like & getrecommendations! Published in 2019 at "Stem Cell Reports"
DOI: 10.1016/j.stemcr.2019.12.005
Abstract: Summary Parkinson's disease (PD) is a complex and highly variable neurodegenerative disease. Familial PD is caused by mutations in several genes with diverse and mostly unknown functions. It is unclear how dysregulation of these genes… read more here.
Keywords: isogenic human; pathogenic pathways; disease; parkinson disease ... See more keywords
Molecular Characterization and Putative Pathogenic Pathways of Tuberous Sclerosis Complex–Associated Renal Cell Carcinoma
Sign Up to like & getrecommendations! Published in 2018 at "Translational Oncology"
DOI: 10.1016/j.tranon.2018.05.010
Abstract: Tuberous sclerosis complex–associated renal cell carcinoma (TSC-RCC) has distinct clinical and histopathologic features and is considered a specific subtype of RCC. The genetic alterations of TSC1 or TSC2 are responsible for the development of TSC.… read more here.
Keywords: mtor pathway; tuberous sclerosis; pathogenic pathways; tsc rcc ... See more keywords
ABCA7 and Pathogenic Pathways of Alzheimer’s Disease
Sign Up to like & getrecommendations! Published in 2018 at "Brain Sciences"
DOI: 10.3390/brainsci8020027
Abstract: The ATP-binding cassette (ABC) reporter family functions to regulate the homeostasis of phospholipids and cholesterol in the central nervous system, as well as peripheral tissues. ABCA7 belongs to the A subfamily of ABC transporters, which… read more here.
Keywords: pathways alzheimer; alzheimer disease; pathogenic pathways; disease ... See more keywords