The Pathogenic Role of Demodex Mites in Rosacea: A Potential Therapeutic Target Already in Erythematotelangiectatic Rosacea?
Sign Up to like & getrecommendations! Published in 2020 at "Dermatology and Therapy"
DOI: 10.1007/s13555-020-00458-9
Abstract: Rosacea is a common facial dermatosis but its definition and classification are still unclear, especially in terms of its links with demodicosis. Triggers of rosacea (ultraviolet light, heat, spicy foods, alcohol, stress, microbes) are currently… read more here.
Keywords: demodex; demodex mites; rosacea; pathogenic role ... See more keywords
Pathogenic role of autoantibodies against inhibitory synapses
Sign Up to like & getrecommendations! Published in 2018 at "Brain Research"
DOI: 10.1016/j.brainres.2018.09.009
Abstract: Diverse neuropsychiatric diseases were recently linked to specific anti-neuronal autoantibodies targeting synaptic proteins. Symptoms can range from epileptic seizures to cognitive impairment to movement disorders, commonly responding to treatment with immunotherapy. Several of these autoantibodies… read more here.
Keywords: inhibitory synapses; autoantibodies inhibitory; pathogenic role; role autoantibodies ... See more keywords
Insights into the pathogenic role of neutrophils in systemic lupus erythematosus
Sign Up to like & getrecommendations! Published in 2022 at "Current Opinion in Rheumatology"
DOI: 10.1097/bor.0000000000000912
Abstract: Purpose of review Although dysregulated adaptive immune response has been considered as the main culprit for systemic lupus erythematosus (SLE), emerging studies have indicated that innate immunity, functioning upstream of adaptive immunity, acts as an… read more here.
Keywords: insights pathogenic; role neutrophils; pathogenic role; systemic lupus ... See more keywords
Thrombospondin-1 Plays a Major Pathogenic Role in Experimental and Human Bronchopulmonary Dysplasia.
Sign Up to like & getrecommendations! Published in 2022 at "American journal of respiratory and critical care medicine"
DOI: 10.1164/rccm.202104-1021oc
Abstract: RATIONALE Extremely preterm infants develop bronchopulmonary dysplasia (BPD), a chronic lung injury that lacks effective treatment. Thrombospondin-1 is an anti-angiogenic protein that activates TGF-β1, a cytokine strongly linked to both experimental and human BPD. OBJECTIVES… read more here.
Keywords: lung; pathogenic role; thrombospondin; experimental human ... See more keywords
Severe eosinophilic asthma: from the pathogenic role of interleukin-5 to the therapeutic action of mepolizumab
Sign Up to like & getrecommendations! Published in 2017 at "Drug Design, Development and Therapy"
DOI: 10.2147/dddt.s150656
Abstract: Mepolizumab is an anti-interleukin-5 (IL-5) humanized monoclonal antibody that has been recently approved as an add-on biological treatment for severe eosinophilic asthma, by both the US Food and Drug Administration (FDA) and the European Medicines… read more here.
Keywords: severe eosinophilic; eosinophilic asthma; pathogenic role; asthma ... See more keywords
Pathogenic role of 25-hydroxycholesterol in cancer development and progression.
Sign Up to like & getrecommendations! Published in 2023 at "Future oncology"
DOI: 10.2217/fon-2022-0819
Abstract: Cholesterol is an essential lipid that serves several important functions, including maintaining the homeostasis of cells, acting as a precursor to bile acid and steroid hormones and preserving the stability of membrane lipid rafts. 25-hydroxycholesterol… read more here.
Keywords: role hydroxycholesterol; development; pathogenic role; cholesterol ... See more keywords
Pathogenic Role of MicroRNA Dysregulation in Podocytopathies
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Physiology"
DOI: 10.3389/fphys.2022.948094
Abstract: MicroRNAs (miRNAs) participate in the regulation of various important biological processes by regulating the expression of various genes at the post-transcriptional level. Podocytopathies are a series of renal diseases in which direct or indirect damage… read more here.
Keywords: role; pathogenic role; microrna dysregulation; role microrna ... See more keywords
IgE in the Pathogenesis of SLE: From Pathogenic Role to Therapeutic Target
Sign Up to like & getrecommendations! Published in 2020 at "Antibodies"
DOI: 10.3390/antib9040069
Abstract: Systemic lupus erythematosus (SLE) is a multifactorial chronic autoimmune disease, marked by the presence of autoantibodies to nuclear antigens belonging to different isotype classes. For several years, IgE antibodies have been incriminated in the development… read more here.
Keywords: sle; pathogenic role; pathogenesis sle; ige pathogenesis ... See more keywords
CC Chemokines in Idiopathic Pulmonary Fibrosis: Pathogenic Role and Therapeutic Potential
Sign Up to like & getrecommendations! Published in 2023 at "Biomolecules"
DOI: 10.3390/biom13020333
Abstract: Idiopathic pulmonary fibrosis (IPF), characterized by progressive worsening of dyspnea and irreversible decline in lung function, is a chronic and progressive respiratory disease with a poor prognosis. Chronic or repeated lung injury results in inflammation… read more here.
Keywords: idiopathic pulmonary; pulmonary fibrosis; pathogenic role; chemokines idiopathic ... See more keywords
mTOR Signaling in Pulmonary Vascular Disease: Pathogenic Role and Therapeutic Target
Sign Up to like & getrecommendations! Published in 2021 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms22042144
Abstract: Pulmonary arterial hypertension (PAH) is a progressive and fatal disease without a cure. The exact pathogenic mechanisms of PAH are complex and poorly understood, yet a number of abnormally expressed genes and regulatory pathways contribute… read more here.
Keywords: pulmonary vascular; mtor signaling; disease; target ... See more keywords