Pathogenic roles of microvesicles in diabetic retinopathy
Sign Up to like & getrecommendations! Published in 2018 at "Acta Pharmacologica Sinica"
DOI: 10.1038/aps.2017.77
Abstract: Diabetic retinopathy (DR) is a common complication of diabetes and has been recognized as the leading cause of blindness in adults. Several interrelated molecular pathways are involved in the development of DR. Microvesicles (MVs) are… read more here.
Keywords: roles microvesicles; pathogenic roles; diabetic retinopathy; microvesicles diabetic ... See more keywords
Pisa Syndrome in Parkinson’s Disease: Pathogenic Roles of Verticality Perception Deficits
Sign Up to like & getrecommendations! Published in 2018 at "Scientific Reports"
DOI: 10.1038/s41598-018-20129-2
Abstract: We elucidated whether verticality misperception is associated with the generation of Pisa syndrome (PS) in patients with Parkinson’s disease (PD). To examine the heterogenous influence of verticality perception, we also identified the characteristics distinguishing between… read more here.
Keywords: pisa syndrome; pathogenic roles; verticality; parkinson disease ... See more keywords
The protective and pathogenic roles of IL-17 in viral infections: friend or foe?
Sign Up to like & getrecommendations! Published in 2019 at "Open Biology"
DOI: 10.1098/rsob.190109
Abstract: Viral infections cause substantial human morbidity and mortality, and are a significant health burden worldwide. Following a viral infection, the host may initiate complex antiviral immune responses to antagonize viral invasion and replication. However, proinflammatory… read more here.
Keywords: antiviral immune; pathogenic roles; immune responses; viral infections ... See more keywords
Reconciling protective and pathogenic roles of the NLRP3 inflammasome in leishmaniasis
Sign Up to like & getrecommendations! Published in 2020 at "Immunological Reviews"
DOI: 10.1111/imr.12886
Abstract: Leishmaniasis is a global health problem that affects more than 2 billion people worldwide. Recent advances in research have demonstrated critical roles for cytoplasmic sensors and inflammasomes during Leishmania spp. infection and pathogenesis. Specifically, several… read more here.
Keywords: leishmania spp; spp infection; pathogenic roles; nlrp3 inflammasome ... See more keywords
Pathogenic Roles of Glutamic Acid Decarboxylase 65 Autoantibodies in Cerebellar Ataxias
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Immunology Research"
DOI: 10.1155/2017/2913297
Abstract: Reports suggesting a pathogenic role of autoantibodies directed against glutamic acid decarboxylase 65 (GAD65Abs) in cerebellar ataxias (CAs) are reviewed, and debatable issues such as internalization of antibodies by neurons and roles of epitopes are… read more here.
Keywords: cerebellar ataxias; glutamic acid; pathogenic roles; gad65ab ... See more keywords
Distinct pathogenic roles for resident and monocyte-derived macrophages in lupus nephritis
Sign Up to like & getrecommendations! Published in 2022 at "JCI Insight"
DOI: 10.1172/jci.insight.159751
Abstract: Lupus nephritis is a serious complication of systemic lupus erythematosus, mediated by IgG immune complex (IC) deposition in kidneys, with limited treatment options. Kidney macrophages are critical tissue sentinels that express IgG-binding Fcγ receptors (FcγRs),… read more here.
Keywords: distinct pathogenic; monocyte derived; lupus nephritis; pathogenic roles ... See more keywords
Pathogenic roles and diagnostic utility of interleukin-18 in autoinflammatory diseases
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.951535
Abstract: Interleukin (IL)-18 is a pleiotropic, pro-inflammatory cytokine involved in the regulation of innate and adaptive immune responses. IL-18 has attracted increasing attention as a key mediator in autoinflammatory diseases associated with the development of macrophage… read more here.
Keywords: utility interleukin; autoinflammatory; autoinflammatory diseases; roles diagnostic ... See more keywords
Pathogenic Roles of RNA-Binding Proteins in Sarcomas
Sign Up to like & getrecommendations! Published in 2022 at "Cancers"
DOI: 10.3390/cancers14153812
Abstract: Simple Summary DNA information can be copied into mRNA (this process is called transcription) and proteins can be subsequently synthesized using the information in mRNA as a template (called translation). Approximately 4000 RNA-binding proteins (RBPs)… read more here.
Keywords: rna binding; types sarcomas; pathogenic roles; roles rna ... See more keywords
Pathogenic Roles of Heparan Sulfate and Its Use as a Biomarker in Mucopolysaccharidoses
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms231911724
Abstract: Heparan sulfate (HS) is an essential glycosaminoglycan (GAG) as a component of proteoglycans, which are present on the cell surface and in the extracellular matrix. HS-containing proteoglycans not only function as structural constituents of the… read more here.
Keywords: biomarker; heparan sulfate; pathogenic roles; sulfate ... See more keywords