Spinal cord extracts of amyotrophic lateral sclerosis spread TDP-43 pathology in cerebral organoids
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DOI: 10.1101/2022.05.05.490760
Abstract: Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder caused by progressive loss of motor neurons and there is currently no effective therapy. Cytoplasmic mislocalization and aggregation of TAR DNA-binding protein 43 kDa (TDP-43) within… read more here.
Keywords: pathogenic tdp; tdp pathology; pathology; cerebral organoids ... See more keywords