Mitochondrial Oxidative Phosphorylation Regulates the Fate Decision between Pathogenic Th17 and Regulatory T Cells.
Sign Up to like & getrecommendations! Published in 2020 at "Cell reports"
DOI: 10.1016/j.celrep.2020.01.022
Abstract: Understanding metabolic pathways that regulate Th17 development is important to broaden therapeutic options for Th17-mediated autoimmunity. Here, we report a pivotal role of mitochondrial oxidative phosphorylation (OXPHOS) for lineage specification toward pathogenic Th17 differentiation. Th17… read more here.
Keywords: fate decision; mitochondrial oxidative; th17; oxidative phosphorylation ... See more keywords
Calcium Signaling Controls Pathogenic Th17 Cell-Mediated Inflammation by Regulating Mitochondrial Function.
Sign Up to like & getrecommendations! Published in 2019 at "Cell metabolism"
DOI: 10.1016/j.cmet.2019.01.019
Abstract: Pathogenic Th17 cells play important roles in many autoimmune and inflammatory diseases. Their function depends on T cell receptor (TCR) signaling and cytokines that activate signal transducer and activator of transcription 3 (STAT3). TCR engagement activates… read more here.
Keywords: th17 cell; mitochondrial function; th17; pathogenic th17 ... See more keywords
Levels of Pathogenic Th17 and Th22 Cells in Patients with Rheumatoid Arthritis
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Immunology Research"
DOI: 10.1155/2022/5398743
Abstract: Rheumatoid arthritis (RA) is a chronic autoimmune condition characterized, among others, by tissue damage and activation/differentiation of proinflammatory lymphocytes. Accordingly, several studies have concluded that type 17 T helper (Th17) cells seem to have an… read more here.
Keywords: th17 cells; th22; rheumatoid arthritis; th17 ... See more keywords
Calcium Signaling in T Cells and Chronic Inflammatory Disorders of the Oral Cavity
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Dental Research"
DOI: 10.1177/0022034521990652
Abstract: Acute immune responses to microbial insults in the oral cavity often progress to chronic inflammatory diseases such as periodontitis and apical periodontitis. Chronic oral inflammation causes destruction of the periodontium, potentially leading to loss of… read more here.
Keywords: oral cavity; th17 cells; inflammatory; chronic inflammatory ... See more keywords
The pathogenic subpopulation of Th17 cells in obesity.
Sign Up to like & getrecommendations! Published in 2021 at "Current pharmaceutical design"
DOI: 10.2174/1381612826666210101154913
Abstract: Obesity is a metabolic disease characterized by a chronic subclinical inflammatory response associated with an imbalance/dysregulation of cellular homeostasis in response to excessive nutrient intake and accumulation. CD4+ Tlymphocytes form different populations, Th1, Th2, Th9,… read more here.
Keywords: subpopulation th17; th17 cells; obesity; th17 ... See more keywords
Differentiation of Pathogenic Th17 Cells Is Negatively Regulated by Let-7 MicroRNAs in a Mouse Model of Multiple Sclerosis
Sign Up to like & getrecommendations! Published in 2019 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2019.03125
Abstract: Multiple sclerosis (MS) is a disabling demyelinating autoimmune disorder of the central nervous system (CNS) which is driven by IL-23- and IL-1β-induced autoreactive Th17 cells that traffic to the CNS and secrete proinflammatory cytokines. Th17… read more here.
Keywords: th17 cells; multiple sclerosis; differentiation; th17 ... See more keywords
SKI Expression Suppresses Pathogenic Th17 Cell Response and Mitigates Experimental Autoimmune Encephalomyelitis
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2021.707899
Abstract: Pathogenic Th17 cells are critically involved in many autoimmune diseases, while non-pathogenic Th17 cells are more immune regulatory. Understanding the mechanisms of the induction and maintenance of pathogenic Th17 cells will benefit the development of… read more here.
Keywords: th17 cell; th17; ski expression; pathogenic th17 ... See more keywords
Proximal and Distal Regions of Pathogenic Th17 Related Chromatin Loci Are Sequentially Accessible During Pathogenicity of Th17
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.864314
Abstract: Pathogenic Th17, featured by their production of pro-inflammatory cytokines, are considered as a key player in most autoimmune diseases. The transcriptome of them is obviously distinct from that of conventional regulatory Th17. However, chromatin accessibility… read more here.
Keywords: tss; patho chars; region; th17 ... See more keywords