Repurposing cancer drugs identifies kenpaullone which ameliorates pathologic pain in preclinical models via normalization of inhibitory neurotransmission
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DOI: 10.1038/s41467-021-26270-3
Abstract: Inhibitory GABA-ergic neurotransmission is fundamental for the adult vertebrate central nervous system and requires low chloride concentration in neurons, maintained by KCC2, a neuroprotective ion transporter that extrudes intracellular neuronal chloride. To identify Kcc2 gene… read more here.
Keywords: pathologic pain; expression; neurotransmission; inhibitory neurotransmission ... See more keywords