Semaphorin 6A phase separation sustains a histone lactylationâdependent lactate buildup in pathological angiogenesis
Sign Up to like & getrecommendations! Published in 2025 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2423677122
Abstract: Significance The most widely used anti-angiogenic agents for ischemic retinopathy, such as anti-VEGF, exhibit unignorable drawbacks due to insufficient efficacy and resistance. Urgent efforts are needed to further elucidate the mechanisms underlying pathological angiogenesis to… read more here.
Keywords: pathological angiogenesis; phase separation; lactylation;
Endothelial Connexins in Developmental and Pathological Angiogenesis.
Sign Up to like & getrecommendations! Published in 2022 at "Cold Spring Harbor perspectives in medicine"
DOI: 10.1101/cshperspect.a041158
Abstract: Connexins (Cxs) constitute a large family of transmembrane proteins that form gap junction channels, which enable the direct transfer of small signaling molecules from cell to cell. In blood vessels, Cx channels allow the endothelial… read more here.
Keywords: endothelial connexins; role; pathological angiogenesis; angiogenesis ... See more keywords
Physiological and pathological angiogenesis in endometrium at the time of embryo implantation
Sign Up to like & getrecommendations! Published in 2017 at "American Journal of Reproductive Immunology"
DOI: 10.1111/aji.12693
Abstract: Embryo establishes contact with the endometrium during implantation. Proper endometrial vascular development and maintenance at the time of embryo implantation is crucial for successful pregnancy. Vascular development at the maternalâembryo interface can be regulated by… read more here.
Keywords: pathological angiogenesis; embryo implantation; time; implantation ... See more keywords
Nogo-B modulates physiological and pathological angiogenesis during development and disease
Sign Up to like & getrecommendations! Published in 2024 at "Physiology"
DOI: 10.1152/physiol.2024.39.s1.1641
Abstract: Angiogenesis, i.e., the formation of new blood vessels, is essential for normal development and functional vessel formation in ischemic diseases. During angiogenesis, endothelial cells (ECs) coordinate migration, proliferation, and metabolic fluxes to adapt to branching… read more here.
Keywords: loss nogo; physiology; pathological angiogenesis; physiological pathological ... See more keywords
Pigment Epithelium-Derived Factor Protects Retinal Neural Cells and Prevents Pathological Angiogenesis in an Ex Vivo Ischemia Model
Sign Up to like & getrecommendations! Published in 2022 at "Oxidative Medicine and Cellular Longevity"
DOI: 10.1155/2022/4199394
Abstract: Ocular ischemia/hypoxia is a severe problem in ophthalmology that can cause vision impairment and blindness. However, little is known about the changes occurring in the existing fully formed choroidal blood vessels. We developed a new… read more here.
Keywords: ischemia; ischemia hypoxia; pigment epithelium; pathological angiogenesis ... See more keywords
CD8+ T Cells Promote Pathological Angiogenesis in Ocular Neovascular Disease
Sign Up to like & getrecommendations! Published in 2023 at "Arteriosclerosis, Thrombosis, and Vascular Biology"
DOI: 10.1161/atvbaha.122.318079
Abstract: Background: CD4+ (cluster of differentation) and CD8+ T cells are increased in the ocular fluids of patients with neovascular retinopathy, yet their role in the disease process is unknown. Methods: We describe how CD8+ T… read more here.
Keywords: pathological angiogenesis; vascular disease; cd8 cells; cd8 ... See more keywords
A transcriptome-based signature of pathological angiogenesis predicts breast cancer patient survival
Sign Up to like & getrecommendations! Published in 2019 at "PLoS Genetics"
DOI: 10.1371/journal.pgen.1008482
Abstract: The specific genes and molecules that drive physiological angiogenesis differ from those involved in pathological angiogenesis, suggesting distinct mechanisms for these seemingly related processes. Unveiling genes and pathways preferentially associated with pathologic angiogenesis is key… read more here.
Keywords: angiogenesis; pathological angiogenesis; breast cancer; signature ... See more keywords