An Intrinsically Nontrimerizing Peptide Probe for Specifically Targeting Pathological Collagen in Connective Tissues
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DOI: 10.1002/adfm.202004532
Abstract: The efficient detection of pathological collagen plays an essential role in the diagnosis, prognosis, and treatment of various critical diseases such as arthritis and tumors. Peptide probes with the (Gly‐Pro‐Hyp)n sequences have been recently discovered… read more here.
Keywords: nontrimerizing peptide; collagen; pathological collagen; intrinsically nontrimerizing ... See more keywords
LOXL4, but not LOXL2, is the critical determinant of pathological collagen cross-linking and fibrosis in the lung
Sign Up to like & getrecommendations! Published in 2023 at "Science Advances"
DOI: 10.1126/sciadv.adf0133
Abstract: Idiopathic pulmonary fibrosis is a progressive fibrotic disease characterized by excessive deposition of (myo)fibroblast produced collagen fibrils in alveolar areas of the lung. Lysyl oxidases (LOXs) have been proposed to be the central enzymes that… read more here.
Keywords: collagen cross; cross linking; collagen; pathological collagen ... See more keywords