Elucidation of pathological mechanism caused by human disease mutation in CaMKIIβ
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Neuroscience Research"
DOI: 10.1002/jnr.25013
Abstract: Recently, we have identified CaMKIIα and CaMKIIβ mutations in patients with neurodevelopmental disorders by whole exome sequencing study. Most CaMKII mutants have increased phosphorylation of Thr286/287, which induces autonomous activity of CaMKII, using cell culture… read more here.
Keywords: mutation camkii; camkii; pathological mechanism; disease ... See more keywords
Cerebral Small Vessel Disease: Neuroimaging Features, Biochemical Markers, Influencing Factors, Pathological Mechanism and Treatment
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Neurology"
DOI: 10.3389/fneur.2022.843953
Abstract: Cerebral small vessel disease (CSVD) is the most common chronic vascular disease involving the whole brain. Great progress has been made in clinical imaging, pathological mechanism, and treatment of CSVD, but many problems remain. Clarifying… read more here.
Keywords: vessel disease; disease; cerebral small; pathological mechanism ... See more keywords
Microbiome Dysbiosis: A Pathological Mechanism at the Intersection of Obesity and Glaucoma
Sign Up to like & getrecommendations! Published in 2023 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms24021166
Abstract: The rate at which obesity is becoming an epidemic in many countries is alarming. Obese individuals have a high risk of developing elevated intraocular pressure and glaucoma. Additionally, glaucoma is a disease of epidemic proportions.… read more here.
Keywords: obesity glaucoma; dysbiosis pathological; dysbiosis; pathological mechanism ... See more keywords
Pathological mechanism of heart failure with preserved ejection fraction in rats based on iTRAQ technology
Sign Up to like & getrecommendations! Published in 2023 at "PeerJ"
DOI: 10.7717/peerj.15280
Abstract: Objective Heart failure with preserved ejection fraction (HFpEF) is a public health problem worldwide. Treatments for the patients with HFpEF are not satisfactory because there is no unified understanding of the pathological mechanism of HFpEF.… read more here.
Keywords: heart failure; preserved ejection; ppar; failure preserved ... See more keywords