Psoriasis: pathological mechanisms, current pharmacological therapies, and emerging drug delivery systems.
Sign Up to like & getrecommendations! Published in 2020 at "Drug discovery today"
DOI: 10.1016/j.drudis.2020.09.023
Abstract: Psoriasis is a chronic autoimmune skin disorder triggered by either genetic factors, environmental factors, life style, or a combination thereof. Clinical investigations have identified pathogenesis, such as T cell and cytokine-mediated, genetic disposition, antimicrobial peptides,… read more here.
Keywords: psoriasis pathological; delivery systems; drug; pathological mechanisms ... See more keywords
Seizures in patients with a phaeochromocytoma/paraganglioma (PPGL): A review of clinical cases and postulated pathological mechanisms.
Sign Up to like & getrecommendations! Published in 2019 at "Revue neurologique"
DOI: 10.1016/j.neurol.2018.11.007
Abstract: The purpose of this work was to expound on the postulated pathological mechanisms through which pheochromocytoma/paraganglioma (PPGL) can cause seizures by conducting a comprehensive review of ten cases and several pathogenic mechanisms. The goal was… read more here.
Keywords: paraganglioma ppgl; review; pathological mechanisms; ppgl ... See more keywords
From pathological mechanisms in Krabbe disease to cutting‐edge therapy: A comprehensive review
Sign Up to like & getrecommendations! Published in 2024 at "Neuropathology"
DOI: 10.1111/neup.12967
Abstract: Since its initial documentation by Knud Krabbe in 1916, numerous studies have scrutinized the characteristics of Krabbe disease (KD) until the identification of the mutation in the GALC gene. In alignment with that, we investigated… read more here.
Keywords: disease; pathological mechanisms; therapy; review ... See more keywords
Early pathological mechanisms in a mouse model of heart failure with preserved ejection fraction
Sign Up to like & getrecommendations! Published in 2024 at "American Journal of Physiology - Heart and Circulatory Physiology"
DOI: 10.1152/ajpheart.00318.2024
Abstract: Heart failure with preserved ejection fraction (HFpEF) constitutes more than half of all HF cases, yet evidence-based therapies remain lacking due to limited understanding of its underlying pathological mechanisms. Our study aimed to uncover early… read more here.
Keywords: fraction; pathological mechanisms; physiology; ejection fraction ... See more keywords
A Review on Adducin from Functional to Pathological Mechanisms: Future Direction in Cancer
Sign Up to like & getrecommendations! Published in 2018 at "BioMed Research International"
DOI: 10.1155/2018/3465929
Abstract: Adducin (ADD) is a family of membrane skeleton proteins including ADD1, ADD2, and ADD3 that are encoded by distinct genes on different chromosomes. Adducin is primarily responsible for the assembly of spectrin-actin network that provides… read more here.
Keywords: functional pathological; adducin functional; mechanisms future; pathological mechanisms ... See more keywords
Abstract 4354856: Pathological mechanisms of Down syndrome-associate pulmonary arterial hypertension
Sign Up to like & getrecommendations! Published in 2025 at "Circulation"
DOI: 10.1161/circ.152.suppl_3.4354856
Abstract: Background: Down syndrome (DS) is the most prevalent chromosomal disorder, caused by trisomy of human chromosome 21. DS is associated with an increased incidence of pulmonary arterial hypertension (PAH). We previously reported that the DYRK1A/PPARG/EGR1… read more here.
Keywords: pparg; pathological mechanisms; arterial hypertension; pulmonary arterial ... See more keywords
Pathological mechanisms and candidate therapeutic approaches in the hearing loss of mice carrying human MIR96 mutations
Sign Up to like & getrecommendations! Published in 2024 at "Genome Medicine"
DOI: 10.1186/s13073-024-01394-5
Abstract: Progressive hearing loss is a common problem in the human population with no effective therapeutics currently available. However, it has a strong genetic contribution, and investigating the genes and regulatory interactions underlying hearing loss offers… read more here.
Keywords: mice carrying; loss; pathological mechanisms; mechanisms candidate ... See more keywords
Pathological mechanisms and treatment progression of Alzheimer’s disease
Sign Up to like & getrecommendations! Published in 2025 at "European Journal of Medical Research"
DOI: 10.1186/s40001-025-02886-9
Abstract: Alzheimer's disease (AD) represents the most prevalent neurodegenerative disorder and leading cause of dementia worldwide, with its incidence rising dramatically in aging populations. This progressive disease is neuropathologically characterized by extracellular amyloid-β (Aβ) plaques, intracellular… read more here.
Keywords: alzheimer disease; disease; treatment; mechanisms treatment ... See more keywords
Anxiolytic Effects of Natural Products: Pathological Mechanisms, Molecular Targets, Therapeutic Prospects
Sign Up to like & getrecommendations! Published in 2025 at "Neuropsychiatric Disease and Treatment"
DOI: 10.2147/ndt.s571692
Abstract: Abstract Anxiety disorders are complex neuropsychiatric conditions with incompletely understood mechanisms, which hinders the development of targeted therapies. Natural products have attracted attention as promising anxiolytic candidates due to their multi-component nature, synergistic effects, and… read more here.
Keywords: pathological mechanisms; anxiolytic effects; natural products; effects natural ... See more keywords
Transcriptomic Changes and Pathological Mechanisms in Familial and Sporadic Idiopathic Restless Legs Syndrome: Implications for Inflammation and Cell Adhesion Molecules
Sign Up to like & getrecommendations! Published in 2025 at "Nature and Science of Sleep"
DOI: 10.2147/nss.s512951
Abstract: Purpose Individuals affected by restless legs syndrome (RLS) tend to have familial predispositions without fully explained by genetic variants, and transcriptomic analysis may help elucidate the pathogenic mechanisms of RLS. The study aims to investigate… read more here.
Keywords: rls patients; pathological mechanisms; transcriptomic changes; legs syndrome ... See more keywords
Current Status of Alzheimer's Disease and Pathological Mechanisms Investigating the Therapeutic Molecular Targets.
Sign Up to like & getrecommendations! Published in 2022 at "Current molecular medicine"
DOI: 10.2174/1566524022666220404112843
Abstract: Alzheimer's disease (AD) is a sort of disarrangement in psychological, biological, or developmental mechanisms basic to mental functions. AD is generally affiliated with marked discomfort and impaired social, professional, or other crucial aspects of life.… read more here.
Keywords: disease pathological; pathological mechanisms; disease; alzheimer disease ... See more keywords