Continuous Suppression of Pathological Retinal and Choroidal Neovascularization in Cynomolgus Monkeys via Noninvasive Ophthalmic Delivery of a Novel Anti-VEGFA Nanobody and Proprietary Penetratin Analog Formulation.
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DOI: 10.1002/advs.202504660
Abstract: Pathological retinal and choroidal neovascularization is a hallmark of several blinding diseases, including diabetic retinopathy and age‐related macular degeneration. While intravitreal anti‐VEGF therapies remain the standard of care, they necessitate frequent injections, posing risks such… read more here.
Keywords: neovascularization; anti vegfa; retinal choroidal; pathological retinal ... See more keywords
Müller cells in pathological retinal angiogenesis
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DOI: 10.1016/j.trsl.2018.12.006
Abstract: &NA; Müller cells are the major glial cells spanning the entire layer of the retina and maintaining retinal structure. Under pathological conditions, Müller cells are involved in retinal angiogenesis, a process of growing new blood… read more here.
Keywords: cells pathological; pathological retinal; retinal angiogenesis; ller cells ... See more keywords
Erdafitinib suppresses pathological retinal angiogenesis via dual targeting of FGFR and VEGFR2 signaling
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DOI: 10.1038/s41598-025-20917-7
Abstract: Pathological retinal angiogenesis drives vision loss in diseases like proliferative diabetic retinopathy (PDR) and retinal vein occlusion (RVO). Erdafitinib, a pan-fibroblast growth factor receptor (FGFR) inhibitor, has shown therapeutic potential in FGFR-mutated urothelial carcinoma. This… read more here.
Keywords: erdafitinib suppresses; angiogenesis; pathological retinal; retinal angiogenesis ... See more keywords
Bioactive lipids and pathological retinal angiogenesis
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DOI: 10.1111/bph.14507
Abstract: Angiogenesis, disruption of the retinal barrier, leukocyte‐adhesion and oedema are cardinal signs of proliferative retinopathies that are associated with vision loss. Therefore, identifying factors that regulate these vascular dysfunctions is critical to target pathological angiogenesis.… read more here.
Keywords: proliferative retinopathies; lipids pathological; angiogenesis; pathological retinal ... See more keywords
Nerve growth factor regulates endothelial cell survival and pathological retinal angiogenesis
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DOI: 10.1111/jcmm.14002
Abstract: The mechanism underlying vasoproliferative retinopathies like retinopathy of prematurity (ROP) is hypoxia‐triggered neovascularisation. Nerve growth factor (NGF), a neurotrophin supporting survival and differentiation of neuronal cells may also regulate endothelial cell functions. Here we studied… read more here.
Keywords: nerve growth; pathological retinal; endothelial cell; growth factor ... See more keywords
Overexpression of Twist1 in vascular endothelial cells promotes pathological retinal angiogenesis in mice
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DOI: 10.24272/j.issn.2095-8137.2021.281
Abstract: Retinal angiogenesis is a critical process for normal retinal function. However, uncontrolled angiogenesis can lead to pathological neovascularization (NV), which is closely related to most irreversible blindness-causing retinal diseases. Understanding the molecular basis behind pathological… read more here.
Keywords: retinal angiogenesis; overexpression twist1; pathological retinal; angiogenesis ... See more keywords