Inflammation in Wound Healing and Pathological Scarring.
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DOI: 10.1089/wound.2021.0161
Abstract: Significance: The aberrant inflammation during wound healing results in pathological scarring, such as hypertrophic scars and keloids. This adversely affects the quality of life of patients due to the disfiguring appearance as well as the… read more here.
Keywords: pathological scarring; healing pathological; wound healing; inflammation wound ... See more keywords
Mechanisms underlying pathological scarring by fibroblasts during wound healing.
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DOI: 10.1111/iwj.14097
Abstract: Pathological scarring is an abnormal outcome of wound healing, which often manifests as excessive proliferation and transdifferentiation of fibroblasts (FBs), and excessive deposition of the extracellular matrix. FBs are the most important effector cells involved… read more here.
Keywords: underlying pathological; wound healing; pathological scarring; mechanisms underlying ... See more keywords
Development and validation of a risk assessment scale for pathological scarring.
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DOI: 10.1111/iwj.14241
Abstract: To develop a risk assessment scale for pathological scarring and validate its psychometric properties. This was a methodological study. Researchers developed the scale based on a literature review, qualitative study and Delphi expert consultation. Subsequently,… read more here.
Keywords: assessment scale; scale; pathological scarring; reliability ... See more keywords
Inhibition of USP4 attenuates pathological scarring by downregulation of the TGF‑β/Smad signaling pathway.
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DOI: 10.3892/mmr.2019.10370
Abstract: Pathological scarring is a result of the hypertrophy of scar tissue during tissue repair following trauma. The aim of the present study was to assess the effect of ubiquitin‑specific protease 4 (USP4) silencing on pathological… read more here.
Keywords: tgf smad; inhibition usp4; control; tissue ... See more keywords