Physiological clearance of tau in the periphery and its therapeutic potential for tauopathies
Sign Up to like & getrecommendations! Published in 2018 at "Acta Neuropathologica"
DOI: 10.1007/s00401-018-1891-2
Abstract: Accumulation of pathological tau is the hallmark of Alzheimer’s disease and other tauopathies and is closely correlated with cognitive decline. Clearance of pathological tau from the brain is a major therapeutic strategy for tauopathies. The… read more here.
Keywords: tau levels; tau; pathological tau; clearance ... See more keywords
DNT1 Downregulation and Increased Ethanol Sensitivity in Transgenic Drosophila Models of Alzheimer's Disease.
Sign Up to like & getrecommendations! Published in 2021 at "Archives of gerontology and geriatrics"
DOI: 10.1016/j.archger.2021.104355
Abstract: Two major pathological hallmarks of Alzheimer's disease (AD) are amyloid plaques and neurofibrillary tangles of hyperphosphorylated tau. Aggregation of amyloid-β (Aβ) is considered as the primary insult in AD. However, failure in treatments based on targetingAβ… read more here.
Keywords: dnt1 downregulation; alzheimer disease; disease; pathological tau ... See more keywords
VPS35 regulates tau phosphorylation and neuropathology in tauopathy
Sign Up to like & getrecommendations! Published in 2019 at "Molecular psychiatry"
DOI: 10.1038/s41380-019-0453-x
Abstract: The vacuolar protein sorting 35 (VPS35) is a major component of the retromer recognition core complex which regulates intracellular protein sorting and trafficking. Deficiency in VPS35 by altering APP/Aβ metabolism has been linked to late-onset… read more here.
Keywords: tau; regulates tau; pathological tau; vps35 ... See more keywords
Constitutive XBP-1s-mediated activation of the endoplasmic reticulum unfolded protein response protects against pathological tau
Sign Up to like & getrecommendations! Published in 2019 at "Nature Communications"
DOI: 10.1038/s41467-019-12070-3
Abstract: To endure over the organismal lifespan, neurons utilize multiple strategies to achieve protein homeostasis (proteostasis). Some homeostatic mechanisms act in a subcellular compartment-specific manner, but others exhibit trans-compartmental mechanisms of proteostasis. To identify pathways protecting… read more here.
Keywords: xbp; tau; endoplasmic reticulum; reticulum unfolded ... See more keywords
Development of a BODIPY-based fluorescent probe for imaging pathological tau aggregates in live cells.
Sign Up to like & getrecommendations! Published in 2017 at "Chemical communications"
DOI: 10.1039/c6cc08826k
Abstract: Neuronal accumulation of tau aggregates is a pathological hallmark in multiple neurodegenerative disorders, collectively called tauopathies. A tau aggregation sensor that can monitor abnormal tau aggregation in neurons would facilitate the study of tau aggregation… read more here.
Keywords: tau aggregation; tau; live cells; tau aggregates ... See more keywords
The inhibition of LSD1 via sequestration contributes to tau-mediated neurodegeneration
Sign Up to like & getrecommendations! Published in 2020 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2013552117
Abstract: Significance We have made the discovery that pathological tau functions through the histone demethylase LSD1 in the Alzheimer’s disease pathway. Thus, we have identified a mechanism that links tau to the downstream neuronal dysfunction pathways.… read more here.
Keywords: tau mediated; tau; neurodegeneration; pathological tau ... See more keywords
Pathological tau signatures and nuclear alterations in neurons, astrocytes and microglia in Alzheimer's disease, progressive supranuclear palsy, and dementia with Lewy bodies
Sign Up to like & getrecommendations! Published in 2022 at "Brain Pathology"
DOI: 10.1111/bpa.13112
Abstract: Accumulation of pathological tau aggregates is a prominent feature in tauopathies that leads during the course of the diseases to neuronal dysfunction before and cell death after. Microglia and astrocytes have been described as playing… read more here.
Keywords: cell; tau; disease; pathology ... See more keywords
Humanized monoclonal antibody armanezumab specific to N-terminus of pathological tau: characterization and therapeutic potency
Sign Up to like & getrecommendations! Published in 2017 at "Molecular Neurodegeneration"
DOI: 10.1186/s13024-017-0172-1
Abstract: BackgroundThe experience from clinical trials indicates that anti-Aβ immunotherapy could be effective in early/pre-clinical stages of AD, whereas at the late stages promoting the clearing of Aβ alone may be insufficient to halt the disease… read more here.
Keywords: tau; mab armanezumab; pathological tau; humanized monoclonal ... See more keywords
Enhancement of therapeutic potential of a naturally occurring human antibody targeting a phosphorylated Ser422 containing epitope on pathological tau
Sign Up to like & getrecommendations! Published in 2018 at "Acta Neuropathologica Communications"
DOI: 10.1186/s40478-018-0562-9
Abstract: Aggregation of tau protein and spreading of tau aggregates are pivotal pathological processes in a range of neurological disorders. Accumulating evidence suggests that immunotherapy targeting tau may be a viable therapeutic strategy. We have previously… read more here.
Keywords: tau; human antibody; antibody; pathological tau ... See more keywords