LncRNA HCP5 promotes LAML progression via PSMB8-mediated PI3K/AKT pathway activation
Sign Up to like & getrecommendations! Published in 2019 at "Naunyn-Schmiedeberg's Archives of Pharmacology"
DOI: 10.1007/s00210-019-01788-y
Abstract: Acute myeloid leukemia is an aggressive myeloid malignancy, characterized by rapid cellular proliferation and generally high mortality. Due to the lack of a complete understanding of AML, its clinical outcomes are still not satisfactory. In… read more here.
Keywords: hcp5; pathway activation; pi3k akt; psmb8 ... See more keywords
A Discrete Dynamical System Approach to Pathway Activation Profiles of Signaling Cascades
Sign Up to like & getrecommendations! Published in 2017 at "Bulletin of Mathematical Biology"
DOI: 10.1007/s11538-017-0296-z
Abstract: In living organisms, cascades of covalent modification cycles are one of the major intracellular signaling mechanisms, allowing to transduce physical or chemical stimuli of the external world into variations of activated biochemical species within the… read more here.
Keywords: dynamical system; pathway activation; discrete dynamical; approach ... See more keywords
Widespread Rewiring of Genetic Networks upon Cancer Signaling Pathway Activation
Sign Up to like & getrecommendations! Published in 2018 at "Cell Systems"
DOI: 10.1016/j.cels.2017.10.015
Abstract: Summary Cellular signaling networks coordinate physiological processes in all multicellular organisms. Within networks, modules switch their function to control signaling activity in response to the cellular context. However, systematic approaches to map the interplay of… read more here.
Keywords: state; pathway activation; rewiring genetic; widespread rewiring ... See more keywords
Role of vitamin D in Wnt pathway activation for colonic epithelial cell differentiation
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Taibah University Medical Sciences"
DOI: 10.1016/j.jtumed.2021.01.012
Abstract: Objectives Inflammatory bowel disease (IBD) is a medical condition that represents a pathological form of inflammation, causing damage to the colonic mucosa. Adjunctive vitamin D therapy may activate the Wnt/β-catenin pathway that results in cell… read more here.
Keywords: pathway activation; cell differentiation; vitamin; cell ... See more keywords
Production and characterization of a novel Delta-like 1 functional unit as a tool for Notch pathway activation and generation of a specific antibody.
Sign Up to like & getrecommendations! Published in 2018 at "Protein expression and purification"
DOI: 10.1016/j.pep.2018.01.008
Abstract: Notch signalling is an evolutionary conserved cell-to-cell communication pathway crucial for development and tissue homeostasis. Abnormal Notch signalling by mutations or deregulated expression of its receptors and/or ligands can lead to cancer making it a… read more here.
Keywords: pathway activation; notch; expression; cancer ... See more keywords
Impairment of the autophagy-lysosomal pathway and activation of pyroptosis in macular corneal dystrophy
Sign Up to like & getrecommendations! Published in 2020 at "Cell Death Discovery"
DOI: 10.1038/s41420-020-00320-z
Abstract: Macular corneal dystrophy (MCD) is ascribed to mutations in the carbohydrate sulfotransferase ( CHST6 ) gene affecting keratan sulfate (KS) hydrophilicity and causing non-sulfated KS to precipitate in keratocytes and the corneal stroma. We investigated… read more here.
Keywords: pathway activation; pyroptosis; macular corneal; corneal dystrophy ... See more keywords
Linking drug target and pathway activation for effective therapy using multi-task learning
Sign Up to like & getrecommendations! Published in 2018 at "Scientific Reports"
DOI: 10.1038/s41598-018-25947-y
Abstract: Despite the abundance of large-scale molecular and drug-response data, the insights gained about the mechanisms underlying treatment efficacy in cancer has been in general limited. Machine learning algorithms applied to those datasets most often are… read more here.
Keywords: pathway activation; target pathway; drug; drug target ... See more keywords
SEPA: Signalling entropy-based algorithm to evaluate personalized pathway activation for survival analysis on pan-cancer data.
Sign Up to like & getrecommendations! Published in 2022 at "Bioinformatics"
DOI: 10.1093/bioinformatics/btac122
Abstract: MOTIVATION Biomarkers with prognostic ability and biological interpretability can be used to support decision-making in the survival analysis. Genes usually form functional modules to play synergistic roles, such as pathways. Predicting significant features from the… read more here.
Keywords: pathway activation; activation; entropy; personalized pathway ... See more keywords
Clinical benefit of ixazomib plus lenalidomide‐dexamethasone in myeloma patients with non‐canonical NF‐κB pathway activation
Sign Up to like & getrecommendations! Published in 2020 at "European Journal of Haematology"
DOI: 10.1111/ejh.13435
Abstract: Abstract Objectives Evaluating potential relationships between progression‐free survival (PFS) and tumor gene expression patterns and mutational status was an exploratory objective of the phase 3 TOURMALINE‐MM1 study (NCT01564537) of ixazomib‐lenalidomide‐dexamethasone (IRd) vs placebo‐Rd in 722… read more here.
Keywords: non canonical; pathway activation; expression; canonical pathway ... See more keywords
Alternative pathway activation: Ever ancient and ever new
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DOI: 10.1111/imr.13132
Abstract: Primitive underpinnings of the alternative pathway (AP), namely, a C3‐like protein, likely arose more than a billion years ago. The development of an AP amplification loop, while greatly enhancing speed and potency, also presents a… read more here.
Keywords: ever ancient; ancient ever; alternative pathway; activation ever ... See more keywords
The susceptibility of the kidney to alternative pathway activation—A hypothesis
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DOI: 10.1111/imr.13168
Abstract: The glomerulus is often the prime target of dysregulated alternative pathway (AP) activation. In particular, AP activation is the key driver of two severe kidney diseases: atypical hemolytic uremic syndrome and C3 glomerulopathy. Both conditions… read more here.
Keywords: susceptibility kidney; alternative pathway; kidney; pathway activation ... See more keywords