Comprehensive analysis of metabolic pathway activity subtypes derived prognostic signature in hepatocellular carcinoma
Sign Up to like & getrecommendations! Published in 2022 at "Cancer Medicine"
DOI: 10.1002/cam4.4858
Abstract: Metabolic reprogramming is one of the hallmarks of cancer, but metabolic pathway activity‐related subtypes of hepatocellular carcinoma (HCC) have not been identified. read more here.
Keywords: hepatocellular carcinoma; metabolic pathway; pathway activity;
In vivo deep network tracing reveals phosphofructokinase-mediated coordination of biosynthetic pathway activity in the myocardium.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of molecular and cellular cardiology"
DOI: 10.1016/j.yjmcc.2021.08.013
Abstract: Glucose metabolism comprises numerous amphibolic metabolites that provide precursors for not only the synthesis of cellular building blocks but also for ATP production. In this study, we tested how phosphofructokinase-1 (PFK1) activity controls the fate… read more here.
Keywords: deep network; biosynthetic pathway; activity; pathway activity ... See more keywords
Relationship of Wnt pathway activity and organ involvement in scleroderma types
Sign Up to like & getrecommendations! Published in 2020 at "International Journal of Rheumatic Diseases"
DOI: 10.1111/1756-185x.13973
Abstract: Scleroderma (SSc) is a chronic inflammatory autoimmune disease characterized by fibrosis in the skin and internal organs. In SSc, the heart, lung, kidney, gastrointestinal (GIS) system, muscle, and peri‐articular structures are damaged. There is no… read more here.
Keywords: organ involvement; relationship; relationship wnt; pathway activity ... See more keywords
Enhanced Rho GTPase pathway activity promotes acquisition of glioblastoma chemoresistance.
Sign Up to like & getrecommendations! Published in 2025 at "Molecular cancer therapeutics"
DOI: 10.1158/1535-7163.mct-25-0039
Abstract: Glioblastoma (GBM) is a highly aggressive tumor primarily treated through surgery, radiotherapy, and chemotherapy. GBM radioresistance involves the activation of the Rho GTPase pathway, actin cytoskeleton polymerization, and the cytoplasmic retention of wild-type p53. Activation… read more here.
Keywords: rho pathway; pathway activity; gbm; p53 ... See more keywords
Abstract A131: Fulvestrant resistance in an MCF-7 model for breast cancer is associated with complete loss of ER pathway activity and gain of MAPK-AP1 pathway activity
Sign Up to like & getrecommendations! Published in 2019 at "Molecular Cancer Therapeutics"
DOI: 10.1158/1535-7163.targ-19-a131
Abstract: Background: 10-15 signal transduction pathways govern major cellular processes, e.g. cell division, differentiation and migration, both in physiology and pathophysiology. They are frequently abnormally active in cancer and can drive cancer growth and metastasis. Resistance… read more here.
Keywords: cancer; activity; resistance; pathway activity ... See more keywords
Abstract C020: Quantitative measurements of functional activity of the TGFβ and MAPK-AP1 pathways in colon cancer provides information on their role in cancer development and metastasis
Sign Up to like & getrecommendations! Published in 2019 at "Molecular Cancer Therapeutics"
DOI: 10.1158/1535-7163.targ-19-c020
Abstract: Background: The advancement of targeted drugs for blocking tumor driving signaling pathway(s) is expected to lead to improved outcome for cancer patients. However, a critical requirement for that is reliable and accurate diagnostics on activity… read more here.
Keywords: activity; cancer; pathway activity; mapk ap1 ... See more keywords
Abstract PO5-21-06: Pathway profiling for prediction of response to neoadjuvant Letrozole therapy in ER positive postmenopausal breast cancer: gaining new insights for targeted treatment
Sign Up to like & getrecommendations! Published in 2024 at "Cancer Research"
DOI: 10.1158/1538-7445.sabcs23-po5-21-06
Abstract: Introduction: The NEOLBC (NCT03283384) study included postmenopausal patients with hormone receptor positive (ER≥50%, PR any), HER2 negative, stage II/III breast cancer. A baseline biopsy was taken prior to start letrozole treatment and after two weeks… read more here.
Keywords: cancer; treatment; breast; pathway activity ... See more keywords
A Test to Quantify NOTCH Pathway Activity in T Cell Acute Lymphoblastic Leukemia Patients
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DOI: 10.1182/blood-2019-122856
Abstract: Background The NOTCH signaling pathway is pivotal for various physiological processes including immune responses, and has been implicated in the pathogenesis in many diseases including T-cell acute lymphoblastic leukemia (T-ALL). Over 70% of T-ALL patient… read more here.
Keywords: notch pathway; pathway activity; activity; employment ... See more keywords
Predict drug sensitivity of cancer cells with pathway activity inference
Sign Up to like & getrecommendations! Published in 2018 at "BMC Medical Genomics"
DOI: 10.1186/s12920-018-0449-4
Abstract: BackgroundPredicting cellular responses to drugs has been a major challenge for personalized drug therapy regimen. Recent pharmacogenomic studies measured the sensitivities of heterogeneous cell lines to numerous drugs, and provided valuable data resources to develop… read more here.
Keywords: drug; predict drug; pathway activity; cancer cells ... See more keywords
Converting melanoma-associated fibroblasts into a tumor-suppressive phenotype by increasing intracellular Notch1 pathway activity
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DOI: 10.1371/journal.pone.0248260
Abstract: Cancer-associated fibroblasts (CAFs) play a crucial role in cancer progression, drug resistance and tumor recurrence. We have recently shown that the Notch pathway determines the tumor-regulatory role of experimentally created ‘CAFs’. Here, we examined the… read more here.
Keywords: melanoma; associated fibroblasts; pathway; notch pathway ... See more keywords
Telomere Maintenance Pathway Activity Analysis Enables Tissue- and Gene-Level Inferences
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DOI: 10.3389/fgene.2021.662464
Abstract: Telomere maintenance is one of the mechanisms ensuring indefinite divisions of cancer and stem cells. Good understanding of telomere maintenance mechanisms (TMM) is important for studying cancers and designing therapies. However, molecular factors triggering selective… read more here.
Keywords: analysis; pathway; telomere maintenance; maintenance pathway ... See more keywords