Drug-pathway association prediction: from experimental results to computational models
Sign Up to like & getrecommendations! Published in 2021 at "Briefings in bioinformatics"
DOI: 10.1093/bib/bbaa061
Abstract: Effective drugs are urgently needed to overcome human complex diseases. However, the research and development of novel drug would take long time and cost much money. Traditional drug discovery follows the rule of one drug-one… read more here.
Keywords: drug pathway; drug; pathway; pathway associations ... See more keywords
DPADM: a novel algorithm for detecting drug-pathway associations based on high-throughput transcriptional response to compounds
Sign Up to like & getrecommendations! Published in 2022 at "Briefings in bioinformatics"
DOI: 10.1093/bib/bbac517
Abstract: Pathway genes functionally participate in the same biological process. They typically act cooperatively, and none is considered dispensable. The dominant paradigm in drug discovery is the one-to-one strategy, which aims to find the most sensitive… read more here.
Keywords: dpadm novel; drug pathway; novel algorithm; drug ... See more keywords
pathDIP: an annotated resource for known and predicted human gene-pathway associations and pathway enrichment analysis
Sign Up to like & getrecommendations! Published in 2017 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkw1082
Abstract: Molecular pathway data are essential in current computational and systems biology research. While there are many primary and integrated pathway databases, several challenges remain, including low proteome coverage (57%), low overlap across different databases, unavailability… read more here.
Keywords: pathdip; analysis; pathway; pathway associations ... See more keywords