PI3K/AKT/mTOR pathway and autophagy regulator genes in paranasal squamous cell carcinoma metastasis
Sign Up to like & getrecommendations! Published in 2020 at "Molecular Biology Reports"
DOI: 10.1007/s11033-020-05458-8
Abstract: Although there are many studies on the role of PI3K/AKT/mTOR pathway and autophagy genes in the mechanism of head and neck cancer formation and prognostic significance, there is no study investigating the role of the… read more here.
Keywords: mtor pathway; pathway autophagy; pi3k akt; metastasis ... See more keywords
Novel target for treating Alzheimer’s Diseases: Crosstalk between the Nrf2 pathway and autophagy
Sign Up to like & getrecommendations! Published in 2021 at "Ageing Research Reviews"
DOI: 10.1016/j.arr.2020.101207
Abstract: In mammals, the Keap1-Nrf2-ARE pathway (henceforth, "the Nrf2 pathway") and autophagy are major intracellular defence systems that combat oxidative damage and maintain homeostasis. p62/SQSTM1, a ubiquitin-binding autophagy receptor protein, links the Nrf2 pathway and autophagy.… read more here.
Keywords: nrf2 pathway; p62 keap1; keap1 nrf2; pathway autophagy ... See more keywords
The role of the Hippo pathway in autophagy in the heart.
Sign Up to like & getrecommendations! Published in 2022 at "Cardiovascular research"
DOI: 10.1093/cvr/cvac014
Abstract: The Hippo pathway, an evolutionarily conserved signaling mechanism, controls organ size and tumorigenesis. Increasing lines of evidence suggest that autophagy, an important mechanism of lysosome-mediated cellular degradation, is regulated by the Hippo pathway, which thereby… read more here.
Keywords: hippo pathway; autophagy heart; role hippo; pathway autophagy ... See more keywords
Physiological Roles of Hippo Signaling Pathway and Autophagy in Dementia.
Sign Up to like & getrecommendations! Published in 2023 at "Current aging science"
DOI: 10.2174/1874609816666230206144212
Abstract: BACKGROUND Dementia is a neurocognitive disorder associated with the aging brain and mainly affects the hippocampus and cerebral cortex. The Hippo signaling pathway and autophagy proteins have been found to be perturbed in the brain… read more here.
Keywords: signaling pathway; autophagy dementia; pathway autophagy; hippo signaling ... See more keywords
Impact of interorganelle coordination between the conventional early secretory pathway and autophagy in cellular homeostasis and stress response
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2023.1069256
Abstract: The conventional early secretory pathway and autophagy are two essential interconnected cellular processes that are crucial for maintaining cellular homeostasis. The conventional secretory pathway is an anabolic cellular process synthesizing and delivering proteins to distinct… read more here.
Keywords: cellular homeostasis; pathway autophagy; conventional early; early secretory ... See more keywords
Nrf2 Pathway and Autophagy Crosstalk: New Insights into Therapeutic Strategies for Ischemic Cerebral Vascular Diseases
Sign Up to like & getrecommendations! Published in 2022 at "Antioxidants"
DOI: 10.3390/antiox11091747
Abstract: Cerebrovascular disease is highly prevalent and has a complex etiology and variable pathophysiological activities. It thus poses a serious threat to human life and health. Currently, pathophysiological research on cerebrovascular diseases is gradually improving, and… read more here.
Keywords: oxidative stress; pathway autophagy; nrf2 pathway; autophagy crosstalk ... See more keywords