Targeting STAT3 signaling pathway in cancer by agents derived from Mother Nature.
Sign Up to like & getrecommendations! Published in 2020 at "Seminars in cancer biology"
DOI: 10.1016/j.semcancer.2020.03.016
Abstract: Signal transducer and activator of transcription (STAT) proteins are latent transcription factors that reside in the cytoplasm of several types of cells. In canonical signaling, upon stimulation by cytokines and growth factors, STATs get activated… read more here.
Keywords: stat3; targeting stat3; signaling pathway; pathway cancer ... See more keywords
Targeting the adenosine pathway for cancer immunotherapy.
Sign Up to like & getrecommendations! Published in 2019 at "Seminars in immunology"
DOI: 10.1016/j.smim.2019.101304
Abstract: Suppression of anti-tumor immunity is recognized as a critical step in the development of many types of cancers. Over the past decade, a multitude of immunosuppressive pathways occurring in the tumor microenvironment (TME) have been… read more here.
Keywords: adenosine pathway; cancer immunotherapy; pathway cancer; cancer ... See more keywords
Bibliometric and Visualized Analysis of the Current Status on STING Signaling Pathway and Cancer
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Oncology"
DOI: 10.1155/2022/5095176
Abstract: Cancer, as the second leading cause of death worldwide, has become an ongoing public health challenge and its treatment has received much attention, with immunotherapy becoming a hot research topic in recent years. The interferon… read more here.
Keywords: pathway cancer; signaling pathway; research; sting signaling ... See more keywords
Targeting the IL-1β pathway for cancer immunotherapy remodels the tumor microenvironment and enhances antitumor immune responses.
Sign Up to like & getrecommendations! Published in 2023 at "Cancer immunology research"
DOI: 10.1158/2326-6066.cir-22-0290
Abstract: High levels of IL-1β can result in chronic inflammation, which in turn can promote tumor growth and metastasis. Inhibition of IL-1β could therefore be a promising therapeutic option in the treatment of cancer. Here, the… read more here.
Keywords: targeting pathway; pathway cancer; canakinumab gevokizumab; tumor microenvironment ... See more keywords
Role of the NFκB-signaling pathway in cancer
Sign Up to like & getrecommendations! Published in 2018 at "OncoTargets and therapy"
DOI: 10.2147/ott.s161109
Abstract: Cancer is a group of cells that malignantly grow and proliferate uncontrollably. At present, treatment modes for cancer mainly comprise surgery, chemotherapy, radiotherapy, molecularly targeted therapy, gene therapy, and immunotherapy. However, the curative effects of… read more here.
Keywords: therapy; role signaling; signaling pathway; pathway cancer ... See more keywords
Advances in Understanding the LncRNA-Mediated Regulation of the Hippo Pathway in Cancer
Sign Up to like & getrecommendations! Published in 2021 at "OncoTargets and therapy"
DOI: 10.2147/ott.s283157
Abstract: Abstract Long noncoding RNAs (lncRNAs) are a class of RNA molecules that are longer than 200 nucleotides and cannot encode proteins. Over the past decade, lncRNAs have been defined as regulatory elements of multiple biological… read more here.
Keywords: understanding lncrna; cancer; advances understanding; hippo ... See more keywords
Editorial: Targeting the Wnt/β-catenin signaling pathway in cancer
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2022.1022174
Abstract: COPYRIGHT © 2022 Patergnani, Buchsbaum and Piazza. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided… read more here.
Keywords: pathway cancer; signaling pathway; targeting wnt; wnt catenin ... See more keywords
The Kynurenine Pathway and Cancer: Why Keep It Simple When You Can Make It Complicated
Sign Up to like & getrecommendations! Published in 2022 at "Cancers"
DOI: 10.3390/cancers14112793
Abstract: Simple Summary The kynurenine pathway has two main physiological roles: (i) it protects specific organs such as the eyes and placenta from strong immune reactions and (ii) it additionally generate in the liver and kidney… read more here.
Keywords: kynurenine pathway; pathway cancer; keep simple; cancer keep ... See more keywords
miRNAs and the Hippo pathway in cancer: Exploring the therapeutic potential (Review).
Sign Up to like & getrecommendations! Published in 2022 at "Oncology reports"
DOI: 10.3892/or.2022.8346
Abstract: Cancer is recognized as the leading cause of death worldwide. The hippo signaling pathway regulates organ size by balancing cell proliferation and cell death; hence dysregulation of the hippo pathway promotes cancer‑like conditions. miRNAs are… read more here.
Keywords: hippo pathway; pathway cancer; review; mirnas hippo ... See more keywords