PARG and BRCA1–BARD1 cooperative function regulates DNA repair pathway choice during gametogenesis
Sign Up to like & getrecommendations! Published in 2022 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkac1153
Abstract: Abstract Meiotic chromosome segregation relies on programmed DNA double-strand break induction. These are in turn repaired by homologous recombination, generating physical attachments between the parental chromosomes called crossovers. A subset of breaks yields recombinant outcomes,… read more here.
Keywords: dna repair; function; pathway choice; parg ... See more keywords
CDK2 phosphorylation of Werner protein (WRN) contributes to WRN's DNA double-strand break repair pathway choice.
Sign Up to like & getrecommendations! Published in 2021 at "Aging cell"
DOI: 10.1111/acel.13484
Abstract: Werner syndrome (WS) is an accelerated aging disorder characterized by genomic instability, which is caused by WRN protein deficiency. WRN participates in DNA metabolism including DNA repair. In a previous report, we showed that WRN… read more here.
Keywords: wrn; protein; pathway choice; phosphorylation ... See more keywords