Evaluation of common genetic variants in vitamin E-related pathway genes and colorectal cancer susceptibility.
Sign Up to like & getrecommendations! Published in 2021 at "Archives of toxicology"
DOI: 10.1007/s00204-021-03078-0
Abstract: Vitamin E is effective for preventing the risk of cancer. However, few studies have elucidated the mechanism of vitamin E in cancer occurrence. Herein, we aimed to identify the genetic variants in vitamin E-related pathway… read more here.
Keywords: colorectal cancer; related pathway; pathway genes; cancer ... See more keywords
Association of serotonergic pathway genes with smoking cessation in a Chinese rural male population.
Sign Up to like & getrecommendations! Published in 2018 at "Addictive behaviors"
DOI: 10.1016/j.addbeh.2018.01.001
Abstract: INTRODUCTION Previous studies have found serotonergic pathway genes have inhibitory effects on dopamine system which may influence smoking addiction. This study examined the associations of serotonergic pathway genes (serotonergic receptor genes, solute carrier family 6… read more here.
Keywords: serotonergic pathway; pathway genes; smoking cessation; cessation ... See more keywords
The Wnt/β-catenin pathway is deregulated in cemento-ossifying fibromas.
Sign Up to like & getrecommendations! Published in 2018 at "Oral surgery, oral medicine, oral pathology and oral radiology"
DOI: 10.1016/j.oooo.2017.10.004
Abstract: OBJECTIVE The molecular pathogenesis of cemento ossifying fibroma (COF) is unclear. The purpose of this study was to investigate mutations in 50 oncogenes and tumor suppressor genes, including APC and CTNNB1, in which mutations in… read more here.
Keywords: cemento ossifying; catenin pathway; pathway genes; wnt catenin ... See more keywords
Differentially expressed JAK-STAT signaling pathway genes and target microRNAs in the spleen of necrotic enteritis-afflicted chicken lines.
Sign Up to like & getrecommendations! Published in 2017 at "Research in veterinary science"
DOI: 10.1016/j.rvsc.2017.05.018
Abstract: The JAK signal transducer and STAT signaling pathway is an important regulator of cell proliferation, differentiation, survival, motility, apoptosis, immune response, and development. In this study, we used RNA-Sequencing, qRT-PCR, and bioinformatics tools to investigate… read more here.
Keywords: pathway genes; jak; stat pathway; jak stat ... See more keywords
Analysis of JAK-STAT signaling pathway genes and their microRNAs in the intestinal mucosa of genetically disparate chicken lines induced with necrotic enteritis.
Sign Up to like & getrecommendations! Published in 2017 at "Veterinary immunology and immunopathology"
DOI: 10.1016/j.vetimm.2017.03.001
Abstract: The JAK-STAT signaling pathway plays a key role in cytokine and growth factor activation and is involved in several cellular functions and diseases. The main objective of this study was to investigate the expression of… read more here.
Keywords: jak; stat signaling; jak stat; pathway genes ... See more keywords
Metabolite profiling and transcriptome analyses reveal novel regulatory mechanisms of melatonin biosynthesis in hickory
Sign Up to like & getrecommendations! Published in 2021 at "Horticulture Research"
DOI: 10.1038/s41438-021-00631-x
Abstract: Studies have shown that melatonin regulates the expression of various elements in the biosynthesis and catabolism of plant hormones. In contrast, the effects of these different plant hormones on the biosynthesis and metabolism of melatonin… read more here.
Keywords: biosynthesis; melatonin biosynthesis; regulatory mechanisms; pathway genes ... See more keywords
Recurrent hotspot mutations in HRAS Q61 and PI3K-AKT pathway genes as drivers of breast adenomyoepitheliomas
Sign Up to like & getrecommendations! Published in 2018 at "Nature Communications"
DOI: 10.1038/s41467-018-04128-5
Abstract: Adenomyoepithelioma of the breast is a rare tumor characterized by epithelial−myoepithelial differentiation, whose genetic underpinning is largely unknown. Here we show through whole-exome and targeted massively parallel sequencing analysis that whilst estrogen receptor (ER)-positive adenomyoepitheliomas… read more here.
Keywords: mutations hras; hotspot mutations; pathway genes; hras q61 ... See more keywords
Association of sonic hedgehog signaling pathway genes IHH, BOC, RAB23a and MIR195-5p, MIR509-3-5p, MIR6738-3p with gastric cancer stage
Sign Up to like & getrecommendations! Published in 2021 at "Scientific Reports"
DOI: 10.1038/s41598-021-86946-0
Abstract: Gastric cancer is the leading cause of cancer-related mortality worldwide. Given the importance of gastric cancer in public health, identifying biomarkers associated with disease onset is an important part of precision medicine. The hedgehog signaling… read more here.
Keywords: gastric cancer; pathway genes; signaling pathway; cancer ... See more keywords
Potential functional variants in SMC2 and TP53 in the AURORA pathway genes and risk of pancreatic cancer.
Sign Up to like & getrecommendations! Published in 2019 at "Carcinogenesis"
DOI: 10.1093/carcin/bgz029
Abstract: The AURORA pathway participates in mitosis and cell division, and alterations in mitosis and cell division can lead to carcinogenesis. Therefore, genetic variants in the AURORA pathway genes may be associated with susceptibility to pancreatic… read more here.
Keywords: smc2 tp53; pancreatic cancer; pathway genes; cancer risk ... See more keywords
Influence of polymorphisms in the Wnt/β-catenin pathway genes on hepatocellular carcinoma risk in a Chinese Han population
Sign Up to like & getrecommendations! Published in 2017 at "Medicine"
DOI: 10.1097/md.0000000000006127
Abstract: Abstract The Wnt/&bgr;-catenin pathway plays a vital role in initiating and sustaining hepatocellular carcinoma (HCC). However, few studies have investigated polymorphisms in the Wnt/&bgr;-catenin signaling pathway genes in the Chinese Han population. The aim of… read more here.
Keywords: hcc; chinese han; polymorphisms wnt; pathway genes ... See more keywords
Three novel genetic variants in NRF2 signaling pathway genes are associated with pancreatic cancer risk
Sign Up to like & getrecommendations! Published in 2019 at "Cancer Science"
DOI: 10.1111/cas.14017
Abstract: Pancreatic cancer (PanC) is one of the most lethal solid malignancies, and metastatic PanC is often present at the time of diagnosis. Although several high‐ and low‐penetrance genes have been implicated in PanC, their roles… read more here.
Keywords: risk; genetic variants; pathway genes; panc ... See more keywords