High‐throughput detection of craniofacial defects in fluorescent zebrafish
Sign Up to like & getrecommendations! Published in 2022 at "Birth Defects Research"
DOI: 10.1002/bdr2.2127
Abstract: Losses and malformations of cranial neural crest cell (cNCC) derivatives are a hallmark of several common brain and face malformations. Nevertheless, the etiology of these cNCC defects remains unknown for many cases, suggesting a complex… read more here.
Keywords: craniofacial defects; detection craniofacial; high throughput; pathway inhibitor ... See more keywords
Endothelial injury and thrombotic microangiopathy in COVID-19: Treatment with the lectin-pathway inhibitor narsoplimab
Sign Up to like & getrecommendations! Published in 2020 at "Immunobiology"
DOI: 10.1016/j.imbio.2020.152001
Abstract: Abstract In COVID-19, acute respiratory distress syndrome (ARDS) and thrombotic events are frequent, life-threatening complications. Autopsies commonly show arterial thrombosis and severe endothelial damage. Endothelial damage, which can play an early and central pathogenic role… read more here.
Keywords: lectin pathway; treatment; pathway inhibitor; covid ... See more keywords
Practical management of the adverse effects of Hedgehog pathway inhibitor therapy for basal cell carcinoma
Sign Up to like & getrecommendations! Published in 2017 at "Journal of the American Academy of Dermatology"
DOI: 10.1016/j.jaad.2016.04.063
Abstract: REFERENCES 1. Piette EW, Rosenbach M. Granuloma annulare: pathogenesis, disease associations and triggers, and therapeutic options. J Am Acad Dermatol. 2016;75:467-479. 2. Piette EW, Rosenbach M. Granuloma annulare: clinical and histologic variants, epidemiology, and genetics.… read more here.
Keywords: hedgehog pathway; pathway inhibitor; practical management; adverse effects ... See more keywords
A trans-Pt(II) hedgehog pathway inhibitor complex with cytotoxicity towards breast cancer stem cells and triple negative breast cancer cells.
Sign Up to like & getrecommendations! Published in 2022 at "Dalton transactions"
DOI: 10.1039/d2dt02865d
Abstract: The first example of a Pt complex of GANT61, a hedgehog (Hh) pathway inhibitor is reported. Reaction of cis-[Pt(II)Cl2(dmso)2] with one equivalent of 4-pyridine carboxaldehyde (4-PCA, control ligand) or one equivalent of GANT61 (Hh pathway… read more here.
Keywords: csc; breast cancer; breast; pathway inhibitor ... See more keywords
Measurement of plasma and platelet tissue factor pathway inhibitor, factor V and Protein S in people with haemophilia
Sign Up to like & getrecommendations! Published in 2019 at "Haemophilia"
DOI: 10.1111/hae.13860
Abstract: Tissue factor pathway inhibitor (TFPI) is a naturally occurring anticoagulant found in plasma, where it circulates bound to lipoproteins, factor V (FV) or Protein S (PS), and in platelets. Therapeutic agents targeting TFPI are under… read more here.
Keywords: factor pathway; pathway inhibitor; tissue factor; factor protein ... See more keywords
Befovacimab, an anti‐tissue factor pathway inhibitor antibody: Early termination of the multiple‐dose, dose‐escalating Phase 2 study due to thrombosis
Sign Up to like & getrecommendations! Published in 2022 at "Haemophilia"
DOI: 10.1111/hae.14595
Abstract: Befovacimab (formerly BAY 1093884) is a fully human monoclonal antibody able to bind to tissue factor pathway inhibitor (TFPI) and developed as a non‐replacement therapy for individuals with haemophilia A/B, with or without inhibitors. read more here.
Keywords: tissue factor; pathway inhibitor; factor pathway; antibody ... See more keywords
Tissue factor pathway inhibitor 2: A potential diagnostic marker for discriminating benign from malignant ovarian tumors
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Obstetrics and Gynaecology Research"
DOI: 10.1111/jog.15345
Abstract: Carbohydrate antigen 125 (CA125), CA19‐9, carcinoembryonic antigen (CEA), human epididymis protein 4 (HE4), and the Risk of Ovarian Malignancy Algorithm (ROMA) are widely used as tumor markers and algorithms for the diagnosis of ovarian cancer… read more here.
Keywords: marker; tissue factor; discriminating benign; factor pathway ... See more keywords
The C‐terminus of tissue factor pathway inhibitor‐α inhibits factor V activation by protecting the Arg1545 cleavage site
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Thrombosis and Haemostasis"
DOI: 10.1111/jth.13559
Abstract: Essentials The C‐terminus of tissue factor pathway inhibitor (TFPIα) binds to the B‐domain of factor V (FV). The functional consequences of this interaction were investigated in plasma and model systems. The TFPIα C‐terminus inhibited thrombin… read more here.
Keywords: terminus; factor pathway; pathway inhibitor; tissue factor ... See more keywords
Regulation of coagulation by tissue factor pathway inhibitor: Implications for hemophilia therapy
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Thrombosis and Haemostasis"
DOI: 10.1111/jth.15697
Abstract: Tissue factor pathway inhibitor (TFPI) is an alternatively spliced anticoagulant protein that primarily dampens the initiation phase of coagulation before thrombin is generated. As such, TFPI’s actions are localized to cells expressing TF and to… read more here.
Keywords: coagulation; tissue factor; factor pathway; inhibitor ... See more keywords